Comparative Analysis of Transcriptional Profile Changes in Larval Zebrafish Exposed to Zinc Oxide Nanoparticles and Zinc Sulfate

详细信息    查看全文

• 作者：Ryeo-Ok Kim ; Jin Soo Choi ; Byoung-Chul Kim…
• 关键词：Zebrafish ; Zinc oxide nanoparticles ; Microarray ; Ingenuity pathway analysis
• 刊名：Bulletin of Environmental Contamination and Toxicology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：98
• 期：2
• 页码：183-189
• 全文大小：
• 刊物主题：Pollution, general; Environmental Health; Ecotoxicology; Soil Science & Conservation; Environmental Chemistry; Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution;
• 出版者：Springer US
• ISSN：1432-0800
• 卷排序：98

文摘

Many studies of the toxic effects of zinc oxide nanoparticles (ZnO NPs) in aquatic organisms have been performed because of increasing ZnO NP use. However, the toxicological pathways are not understood. In this study, ZnO NPs were found to be more toxic than ZnSO₄ to zebrafish larvae, but ZnO NP toxicity did not involve transcript alterations. Biological processes affected by ZnO NPs and ZnSO₄ were investigated by performing ingenuity pathway analysis on differently expressed genes in larvae exposed to sub-lethal ZnO NP and ZnSO₄ concentrations. We identified upregulated and downregulated differently expressed genes in fish exposed to ZnO NPs and ZnSO₄, and found that ZnO NPs slightly induced cell differentiation and pathways associated with the immune system and activated several key genes involved in cancer cell signaling. The results may be key to predicting and elucidating the mechanisms involved in ZnO NP and ZnSO₄ toxicity in zebrafish larvae.