New strategies for the repair of spinal cord injury
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- 作者：Zhourui Wu (1)
Ziru Zhao (1)
Yan Yu (1)
Xiao Hu (1)
Wei Xu (1)
Zhili Zeng (1)
Yi Eve Sun (2)
Liming Cheng (1) - 关键词：Spinal cord injury ; Secondary injury ; Repair ; Regeneration ; Stem cells
- 刊名：Chinese Science Bulletin
- 出版年：2014
- 出版时间：November 2014
- 年：2014
- 卷：59
- 期：31
- 页码：4041-4049
- 全文大小：200 KB
- 参考文献：1. National Spinal Cord Injury Statistical Center (NSCISC) (2012) Spinal cord injury facts and figures at a glance. J Spinal Cord Med 35:197鈥?98 CrossRef
2. Wu J, Kharebava G, Piao C et al (2012) Inhibition of E2F1/CDK1 pathway attenuates neuronal apoptosis / in vitro and confers neuroprotection after spinal cord injury / in vivo. PLoS One 7:e42129 CrossRef
3. Kim HJ, Lee JH, Kim SH (2010) Therapeutic effects of human mesenchymal stem cells on traumatic brain injury in rats: secretion of neurotrophic factors and inhibition of apoptosis. J Neurotrauma 27:131鈥?38 CrossRef
4. Kamei N, Tanaka N, Oishi Y et al (2007) BDNF, NT-3, and NGF released from transplanted neural progenitor cells promote corticospinal axon growth in organotypic cocultures. Spine (Phila Pa 1976) 32:1272鈥?278 CrossRef
5. Lee SH, Chung YN, Kim YH et al (2009) Effects of human neural stem cell transplantation in canine spinal cord hemisection. Neurol Res 31:996 CrossRef
6. Runyan SA, Phelps PE (2009) Mouse olfactory ensheathing glia enhance axon outgrowth on a myelin substrate / in vitro. Exp Neurol 216:95鈥?04 CrossRef
7. Han Q, Jin W, Xiao Z et al (2010) The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody. Biomaterials 31:9212鈥?220 CrossRef
8. Iskandar BJ, Rizk E, Meier B et al (2010) Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. J Clin Invest 120:1603鈥?616 CrossRef
9. Kruse F, Bosse F, Vogelaar CF et al (2011) Cortical gene expression in spinal cord injury and repair: insight into the functional complexity of the neural regeneration program. Front Mol Neurosci 4:26 CrossRef
10. Ramon-Cueto A, Cordero MI, Santos-Benito FF et al (2000) Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia. Neuron 25:425鈥?35 CrossRef
11. Boyd JG, Doucette R, Kawaja MD (2005) Defining the role of olfactory ensheathing cells in facilitating axon remyelination following damage to the spinal cord. Faseb J 19:694鈥?03 CrossRef
12. Croft AP, Przyborski SA (2009) Mesenchymal stem cells expressing neural antigens instruct a neurogenic cell fate on neural stem cells. Exp Neurol 216:329鈥?41 CrossRef
13. Yu D, Neeley WL, Pritchard CD et al (2009) Blockade of peroxynitrite-induced neural stem cell death in the acutely injured spinal cord by drug-releasing polymer. Stem Cells 27:1212鈥?222 CrossRef
14. Galindo LT, Filippo TR, Semedo P et al (2011) Mesenchymal stem cell therapy modulates the inflammatory response in experimental traumatic brain injury. Neurol Res Int 2011:564089 CrossRef
15. Xu X, Geremia N, Bao F et al (2011) Schwann cell coculture improves the therapeutic effect of bone marrow stromal cells on recovery in spinal cord-injured mice. Cell Transpl 20:1065鈥?086 CrossRef
16. Dumitriu IE, Baruah P, Valentinis B et al (2005) Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products. J Immunol 174:7506鈥?515 CrossRef
17. Yiu G, He Z (2006) Glial inhibition of CNS axon regeneration. Nat Rev Neurosci 7:617鈥?27 CrossRef
18. Sofroniew MV (2005) Reactive astrocytes in neural repair and protection. Neuroscientist 11:400鈥?07 CrossRef
19. Xia Y, Zhao T, Li J et al (2008) Antisense vimentin cDNA combined with chondroitinase ABC reduces glial scar and cystic cavity formation following spinal cord injury in rats. Biochem Biophys Res Commun 377:562鈥?66 CrossRef
20. Buss A, Pech K, Kakulas BA et al (2009) NG2 and phosphacan are present in the astroglial scar after human traumatic spinal cord injury. BMC Neurol 9:32 CrossRef
21. Moviglia GA, Fernandez Vina R, Brizuela JA et al (2006) Combined protocol of cell therapy for chronic spinal cord injury. Report on the electrical and functional recovery of two patients. Cytotherapy 8:202鈥?09 CrossRef
22. Meng XT, Li C, Dong ZY et al (2008) Co-transplantation of bFGF-expressing amniotic epithelial cells and neural stem cells promotes functional recovery in spinal cord-injured rats. Cell Biol Int 32:1546鈥?558 CrossRef
23. Ban DX, Ning GZ, Feng SQ et al (2011) Combination of activated Schwann cells with bone mesenchymal stem cells: the best cell strategy for repair after spinal cord injury in rats. Regen Med 6:707鈥?20 CrossRef
24. Solomon A, Rosenblatt M, Monroy D et al (2001) Suppression of interleukin 1alpha and interleukin 1beta in human limbal epithelial cells cultured on the amniotic membrane stromal matrix. Br J Ophthalmol 85:444鈥?49 CrossRef
25. Jorgensen C, Gordeladze J, Noel D (2004) Tissue engineering through autologous mesenchymal stem cells. Curr Opin Biotechnol 15:406鈥?10 CrossRef
26. Comolli N, Neuhuber B, Fischer I et al (2009) / In vitro analysis of PNIPAAm-PEG, a novel, injectable scaffold for spinal cord repair. Acta Biomater 5:1046鈥?055 CrossRef
27. Hejcl A, Lesny P, Pradny M et al (2008) Biocompatible hydrogels in spinal cord injury repair. Physiol Res 57(Suppl 3):S121鈥揝132
28. Thonhoff JR, Lou DI, Jordan PM et al (2008) Compatibility of human fetal neural stem cells with hydrogel biomaterials / in vitro. Brain Res 1187:42鈥?1 CrossRef
29. Hejcl A, Lesny P, Pradny M et al (2009) Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 6: 3D hydrogels with positive and negative surface charges and polyelectrolyte complexes in spinal cord injury repair. J Mater Sci Mater Med 7:1571鈥?577 CrossRef
30. Johnson PJ, Parker SR, Sakiyama-Elbert SE (2009) Fibrin-based tissue engineering scaffolds enhance neural fiber sprouting and delay the accumulation of reactive astrocytes at the lesion in a subacute model of spinal cord injury. J Biomed Mater Res A 92:152
31. Wichterle H, Lieberam I, Porter JA et al (2002) Directed differentiation of embryonic stem cells into motor neurons. Cell 110:385鈥?97 CrossRef
32. Liang P, Jin LH, Liang T et al (2006) Human neural stem cells promote corticospinal axons regeneration and synapse reformation in injured spinal cord of rats. Chin Med J (Engl) 119:1331鈥?338
33. Kumamaru H, Ohkawa Y, Saiwai H et al (2012) Direct isolation and RNA-seq reveal environment-dependent properties of engrafted neural stem/progenitor cells. Nat Commun 3:1140 CrossRef
34. Gamsiz ED, Ouyang Q, Schmidt M et al (2012) Genome-wide transcriptome analysis in murine neural retina using high-throughput RNA sequencing. Genomics 99:44鈥?1 CrossRef
35. Kumamaru H, Saiwai H, Kubota K, Kobayakawa K, Yokota K, Ohkawa Y, Shiba K, Iwamoto Y, Okada S (2013) Therapeutic activities of engrafted neural stem/precursor cells are not dormant in the chronically injured spinal cord. Stem Cells 31:1535鈥?547
36. Yang ML, Li JJ, So KF et al (2012) Efficacy and safety of lithium carbonate treatment of chronic spinal cord injuries: a double-blind, randomized, placebo-controlled clinical trial. Spinal Cord 50:141鈥?46 CrossRef
37. Wong YW, Tam S, So KF et al (2011) A three-month, open-label, single-arm trial evaluating the safety and pharmacokinetics of oral lithium in patients with chronic spinal cord injury. Spinal Cord 49:94鈥?8 CrossRef
38. Cai J, Li W, Su H et al (2010) Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells. J Biol Chem 285:11227鈥?1234 CrossRef
39. Meissner-Roloff M, Young W, Rangaka I et al (2012) Pilot social feasibility study for the establishment of a public human umbilical cord blood stem cell bank in South Africa. Stem Cell Rev 8:1066鈥?075 CrossRef
40. Anderson DK, Beattie M, Blesch A et al (2005) Recommended guidelines for studies of human subjects with spinal cord injury. Spinal Cord 43:453鈥?58 CrossRef
41. Harkema S, Gerasimenko Y, Hodes J et al (2011) Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study. Lancet 377:1938鈥?947 CrossRef
42. Li W, Wang F, Wang Z et al (2009) Six-channel neural signal regeneration integrated circuit. Conf Proc IEEE Eng Med Biol Soc 2009:1627鈥?630
43. Yarkony GM, Roth EJ, Meyer PR Jr et al (1990) Spinal cord injury care system: fifteen-year experience at the Rehabilitation Institute of Chicago. Paraplegia 28:321鈥?29 CrossRef
44. Huang ME, Sliwa JA (2011) Inpatient rehabilitation of patients with cancer: efficacy and treatment considerations. PM R 3:746鈥?57 CrossRef
45. Dzhala VI, Talos DM, Sdrulla DA et al (2005) NKCC1 transporter facilitates seizures in the developing brain. Nat Med 11:1205鈥?213 CrossRef
46. Xu JC, Lytle C, Zhu TT et al (1994) Molecular cloning and functional expression of the bumetanide-sensitive Na鈥揔鈥揅l cotransporter. Proc Natl Acad Sci USA 91:2201鈥?205 CrossRef
47. Kanehira M, Kaifu T, Maya K et al (2006) Novel mast cell lines with enhanced proliferative and degranulative abilities established from temperature-sensitive SV40 large T antigen transgenic mice. J Biochem 140:211鈥?20 CrossRef
48. Tu Y, Chen C, Sun HT et al (2012) Combination of temperature-sensitive stem cells and mild hypothermia: a new potential therapy for severe traumatic brain injury. J Neurotrauma 29:2393鈥?403 CrossRef
49. Hu R, Duan B, Wang D et al (2011) Role of acid-sensing ion channel 1a in the secondary damage of traumatic spinal cord injury. Ann Surg 254:353鈥?62 CrossRef
50. Kohno S, Murata T, Koide N et al (2011) Establishment and characterization of a noradrenergic adrenal chromaffin cell line, tsAM5NE, immortalized with the temperature-sensitive SV40 T-antigen. Cell Biol Int 35:325鈥?34 CrossRef
51. Feng SQ, Kong XH, Liu Y et al (2009) Regeneration of spinal cord with cell and gene therapy. Orthop Surg 1:153鈥?63 CrossRef
52. Lakatos A, Franklin RJ, Barnett SC (2000) Olfactory ensheathing cells and Schwann cells differ in their / in vitro interactions with astrocytes. Glia 32:214鈥?25 CrossRef
53. Fairless R, Barnett SC (2005) Olfactory ensheathing cells: their role in central nervous system repair. Int J Biochem Cell Biol 37:693鈥?99 CrossRef
54. Cao L, Su Z, Zhou Q et al (2006) Glial cell line-derived neurotrophic factor promotes olfactory ensheathing cells migration. Glia 54:536鈥?44 CrossRef
55. Cao L, Zhu YL, Su Z et al (2007) Olfactory ensheathing cells promote migration of Schwann cells by secreted nerve growth factor. Glia 55:897鈥?04 CrossRef
56. Wu MM, Fan DG, Tadmori I et al (2010) Death of axotomized retinal ganglion cells delayed after intraoptic nerve transplantation of olfactory ensheathing cells in adult rats. Cell Transpl 19:159鈥?66 CrossRef
57. Ulloa L, Messmer D (2006) High-mobility group box 1 (HMGB1) protein: friend and foe. Cytokine Growth Factor Rev 17:189鈥?01 CrossRef
58. Liu G, Detloff MR, Miller KN et al (2012) Exercise modulates microRNAs that affect the PTEN/mTOR pathway in rats after spinal cord injury. Exp Neurol 233:447鈥?56 CrossRef
59. Liu K, Lu Y, Lee JK et al (2010) PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat Neurosci 13:1075鈥?081 CrossRef
60. Wang B, Xiao Z, Chen B et al (2008) Nogo-66 promotes the differentiation of neural progenitors into astroglial lineage cells through mTOR-STAT3 pathway. PLoS One 3:e1856 CrossRef
61. Ochs G, Penn RD, York M et al (2000) A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 1:201鈥?06 CrossRef
62. Jang SW, Liu X, Yepes M et al (2010) A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci USA 107:2687鈥?692 CrossRef
63. Kanno H, Ozawa H, Sekiguchi A et al (2012) The role of mTOR signaling pathway in spinal cord injury. Cell Cycle 11:3175鈥?179 CrossRef
64. Di Giovanni S (2009) Molecular targets for axon regeneration: focus on the intrinsic pathways. Expert Opin Ther Targets 13:1387鈥?398 CrossRef
65. Ibarra A, Diaz-Ruiz A (2006) Protective effect of cyclosporin-A in spinal cord injury: an overview. Curr Med Chem 13:2703鈥?710 CrossRef
66. Coutts M, Keirstead HS (2008) Stem cells for the treatment of spinal cord injury. Exp Neurol 209:368鈥?77 CrossRef
67. Eftekharpour E, Karimi-Abdolrezaee S, Fehlings MG (2008) Current status of experimental cell replacement approaches to spinal cord injury. Neurosurg Focus 24:E19 CrossRef
68. Kim SU, de Vellis J (2009) Stem cell-based cell therapy in neurological diseases: a review. J Neurosci Res 87:2183鈥?200 CrossRef
69. Bretzner F, Gilbert F, Baylis F et al (2011) Target populations for first-in-human embryonic stem cell research in spinal cord injury. Cell Stem Cell 8:468鈥?75 CrossRef
70. Sykov谩 E, Homola A, Mazanec R et al (2006) Autologous bone marrow transplantation in patients with subacute and chronic spinal cord injury. Cell Transplant 15:675鈥?87 CrossRef
71. Akiyama K, Chen C, Wang D et al (2012) Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis. Cell Stem Cell 10:544鈥?55 CrossRef
72. Han Q, Sun W, Lin H et al (2009) Linear ordered collagen scaffolds loaded with collagen-binding brain-derived neurotrophic factor improve the recovery of spinal cord injury in rats. Tissue Eng Part A 15:2927鈥?935 CrossRef
73. Liang W, Han Q, Jin W et al (2010) The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding BDNF. Biomaterials 31:8634鈥?641 CrossRef
74. Ding T, Luo ZJ, Zheng Y et al (2010) Rapid repair and regeneration of damaged rabbit sciatic nerves by tissue-engineered scaffold made from nano-silver and collagen type I. Injury 41:522鈥?27 CrossRef
75. Sedy J, Urdzikova L, Jendelova P et al (2008) Methods for behavioral testing of spinal cord injured rats. Neurosci Biobehav Rev 32:550鈥?80 CrossRef
76. Fuller TF, Ghazalpour A, Aten JE et al (2007) Weighted gene coexpression network analysis strategies applied to mouse weight. Mamm Genome 18:463鈥?72 CrossRef
77. Chen Y, Huang K, Nakatsu MN et al (2013) Identification of novel molecular markers through transcriptomic analysis in human fetal and adult corneal endothelial cells. Hum Mol Genet 22:1271鈥?279 CrossRef
78. Haas BE, Horvath S, Pietilainen KH et al (2012) Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes. BMC Med Genomics 5:61 CrossRef
79. Tang W, Gao Y, Li Y et al (2012) Gene networks implicated in diabetic kidney disease. Eur Rev Med Pharmacol Sci 16:1967鈥?973
80. Ma S, Huang Y, Huang J et al (2012) Gene network-based cancer prognosis analysis with sparse boosting. Genet Res (Camb) 94:205鈥?21 CrossRef
81. Tang HL, Sun HP, Wu X et al (2011) Detection of neural stem cells function in rats with traumatic brain injury by manganese-enhanced magnetic resonance imaging. Chin Med J (Engl) 124:1848鈥?853
82. Hu SL, Lu PG, Zhang LJ et al (2012) / In vivo magnetic resonance imaging tracking of SPIO-labeled human umbilical cord mesenchymal stem cells. J Cell Biochem 113:1005鈥?012 CrossRef
83. Gradinaru V, Zhang F, Ramakrishnan C et al (2010) Molecular and cellular approaches for diversifying and extending optogenetics. Cell 141:154鈥?65 CrossRef
84. Herrera JJ, Chacko T, Narayana PA (2008) Histological correlation of diffusion tensor imaging metrics in experimental spinal cord injury. J Neurosci Res 86:443鈥?47 CrossRef
85. Budde MD, Kim JH, Liang HF et al (2007) Toward accurate diagnosis of white matter pathology using diffusion tensor imaging. Magn Reson Med 57:688鈥?95 CrossRef
86. Mori S, Zhang J (2006) Principles of diffusion tensor imaging and its applications to basic neuroscience research. Neuron 51:527鈥?39 CrossRef
87. Tonnesen J, Parish CL, Sorensen AT et al (2011) Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an / in vitro Parkinson model. PLoS One 6:e17560 CrossRef
88. Cheung MM, Li DT, Hui ES et al (2009) / In vivo diffusion tensor imaging of chronic spinal cord compression in rat model. Conf Proc IEEE Eng Med Biol Soc 2009:2715鈥?718
89. Curt A, Dietz V (1999) Electrophysiological recordings in patients with spinal cord injury: significance for predicting outcome. Spinal Cord 37:157鈥?65 CrossRef
90. Xie J, Boakye M (2008) Electrophysiological outcomes after spinal cord injury. Neurosurg Focus 25:E11 CrossRef - 作者单位：Zhourui Wu (1)
Ziru Zhao (1)
Yan Yu (1)
Xiao Hu (1)
Wei Xu (1)
Zhili Zeng (1)
Yi Eve Sun (2)
Liming Cheng (1)
1. Department of Spine Surgery, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China
2. Translational Stem Cell Center, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China - ISSN：1861-9541
文摘
Spinal cord injury (SCI) leads to several neurologic damages to patients with sensory and motor function loss. Although some inspiring results were reported in animal, even in non-human primate models, the clinical translation of these research achievements barely move forward for the SCI patients. This review mainly focused on the pathogenesis of the primary and secondary injury, the clinical therapies and the new technologies in spinal cord injury. Moreover, the key scientific issues on this field were discussed in the review. Finally, some suggestions were proposed for the scientific and clinical researches.