Clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer
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- 作者：Ba?ak Varol (1)
?zlem Co?kun (2)
Senem Karabulut (3)
Kür?at Rahmi Serin (4)
Oktar Aso?lu (4)
I??l Albeniz (1)
Faruk Ta? (3)
Rüstem Nurten (1) - 关键词：Colorectal cancer ; ADP ; ribosylation ; NAD glycohydrolase activity ; Serum
- 刊名：Tumor Biology
- 出版年：2014
- 出版时间：June 2014
- 年：2014
- 卷：35
- 期：6
- 页码：5575-5582
- 全文大小：
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?zlem Co?kun (2)
Senem Karabulut (3)
Kür?at Rahmi Serin (4)
Oktar Aso?lu (4)
I??l Albeniz (1)
Faruk Ta? (3)
Rüstem Nurten (1)
1. ?stanbul Faculty of Medicine, Department of Biophysics, ?stanbul University, ?apa-?stanbul, Turkey
2. Faculty of Medicine, Department of Biophysics, Onsekiz Mart University, ?anakkale, Turkey
3. Institute of Oncology, ?stanbul University, Capa-Istanbul, Turkey
4. Department of Surgery, Liv Hospital, Ulus-?stanbul, Turkey - ISSN：1423-0380
文摘
The objective of this study was to evaluate the clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer (CRC). A total of 108 patients with CRC who underwent curative surgery and 20 healthy volunteers were enrolled in this study. ADP-ribosylation and NAD glycohydrolase activity levels were determined. The association of ADP-ribosylation and NAD glycohydrolase with clinical and laboratory factors and their impact on overall survival (OS) and disease free survival (DFS) were shown. The preoperative ADP-ribosylation and NAD glycohydrolase activity levels were significantly higher in patients with CRC than in the control group (p-lt;-.001). ADP-ribosylation and NAD glycohydrolase activity levels were correlated with tumor stage (p--.05, p--.001), stage of disease (p-lt;-.001, p-lt;-.001), serum CEA level (p-lt;-.001, p-lt;-.001), and site of lesion (p-lt;-.001, p-lt;-.001), respectively. Patients with high ADP-ribosylation had significantly unfavorable OS and DFS compared with those with lower levels (p-lt;-.001, p-lt;-.001), respectively. Moreover, the patients with high NAD glycohydrolase activity showed significantly worse OS and DFS rates, similar to ADP-ribosylation. Serum levels of ADP-ribosylation and NAD glycohydrolase activity correlate well with tumor stage, stage of disease, serum CEA level, and site of lesion. In conclusion, elevated levels of preoperative ADP-ribosylation and NAD glycohydrolase levels in serum are associated with poor prognosis in patients with CRC.