Effects of dentifrices differing in fluoride compounds on artificial enamel caries lesions in vitro

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• 作者：R. J. Wierichs ; H. Zelck ; C. E. Doerfer ; P. Appel ; S. Paris…
• 关键词：Demineralization ; Stannous fluoride ; Amine fluoride ; Sodium fluoride ; In vitro
• 刊名：Odontology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：105
• 期：1
• 页码：36-45
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Dentistry; Oral and Maxillofacial Surgery;
• 出版者：Springer Japan
• ISSN：1618-1255
• 卷排序：105

文摘

The aim of this study was to compare the caries-preventive effect of a stabilized stannous fluoride/sodium fluoride dentifrice containing sodium hexametaphosphate with those of a regular, solely sodium fluoride-containing and amine fluoride-containing dentifrice on pre-demineralized bovine enamel specimens using a pH-cycling model. Bovine enamel specimens with two artificial lesions each were prepared. Baseline mineral loss of both lesions was analyzed using transversal microradiography (TMR). Eighty-five specimens with a mean (SD) baseline mineral loss of 3393 (683) vol% × µm were selected and randomly allocated to five groups (n = 13/15). Treatments during pH-cycling (28 days and 2 × 20 min demineralization/day) were: brushing twice daily with slurries of AmF (1400 ppm F−), NaF (1450 ppm F−), SnF₂/NaF (1100 ppm F−/350 ppm F−), and fluoride-free (FF) dentifrices or they were immersed in distilled water and remained unbrushed (NB). Subsequently, from each specimen one lesion was covered with acid-resistant varnish, while the remaining lesion was demineralized for another 14 days. Differences in integrated mineral loss (∆∆Z) were calculated between values before and after pH-cycling (∆∆Z_E1) as well as before pH-cycling and after second demineralization (∆∆Z_E2) using TMR. Treatments AmF and NaF induced a significantly higher mineral gain (∆∆Z_E1/∆∆Z_E2) compared to treatments FF and NB (p < 0.05; ANOVA test). Except for treatments AmF and NaF no significant differences in mineral loss between before and after pH-cycling could be observed (p < 0.05; t test) [∆∆Z_E1: AmF:1563 (767); NaF:1222 (1246); SnF₂/NaF:258 (1259); FF:−52 (1223); NB:−151 (834)]. Both dentifrices with either AmF or NaF promoted remineralization, whereas SnF₂/NaF dentifrice did not promote remineralization in a biofilm-free pH-cycling model.