The association of polymorphisms of TLR4 and CD14 genes with susceptibility to sepsis in a Chinese population
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- 作者：Haiyan Wang ; Yesheng Wei ; Yi Zeng ; Yueqiu Qin ; Bin Xiong ; Gang Qin…
- 关键词：Sepsis ; Single nucleotide polymorphism ; TLR4 ; CD14
- 刊名：BMC Medical Genetics
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：15
- 期：1
- 全文大小：375 KB
- 参考文献：1. Horakova, K, Chylkova, A, Kolorz, M, Bartosova, L, Pechacek, V, Starostka, D, Wroblova, K (2012) Polymorphism G-308A in the promoter of the tumor necrosis factor-alpha gene and its association with the risk of venous thromboembolism. Blood Coagul Fibrinolysis 23: pp. 316-319 CrossRef
2. Mayr, FB, Yende, S, Angus, DC (2014) Epidemiology of severe sepsis. Virulence 5: pp. 4-11 CrossRef
3. Cooke, GS, Hill, AV (2001) Genetics of susceptibility to human infectious disease. Nat Rev Genet 2: pp. 967-977 CrossRef
4. Hill, AV (2001) The genomics and genetics of human infectious disease susceptibility. Annu Rev Genomics Hum Genet 2: pp. 373-400 CrossRef
5. Barber, RC, Aragaki, CC, Chang, LY, Purdue, GF, Hunt, JL, Arnoldo, BD, Horton, JW (2007) CD14-159 C allele is associated with increased risk of mortality after burn injury. Shock 27: pp. 232-237 CrossRef
6. Stanilova, SA (2010) Functional relevance of IL-10 promoter polymorphisms for sepsis development. Crit Care 14: pp. 119 CrossRef
7. Teuffel, O, Ethier, MC, Beyene, J, Sung, L (2010) Association between tumor necrosis factor-alpha promoter ?08 A/G polymorphism and susceptibility to sepsis and sepsis mortality: a systematic review and meta-analysis. Crit Care Med 38: pp. 276-282 CrossRef
8. Fahy, RJ, Exline, MC, Gavrilin, MA, Bhatt, NY, Besecker, BY, Sarkar, A, Hollyfield, JL, Duncan, MD, Nagaraja, HN, Knatz, NL, Hall, M, Wewers, MD (2008) Inflammasome mRNA expression in human monocytes during early septic shock. Am J Respir Crit Care Med 177: pp. 983-988 CrossRef
9. Pachot, A, Monneret, G, Voirin, N, Leissner, P, Venet, F, Bohe, J, Payen, D, Bienvenu, J, Mougin, B, Lepape, A (2005) Longitudinal study of cytokine and immune transcription factor mRNA expression in septic shock. Clin Immunol 114: pp. 61-69 CrossRef
10. Agnese, DM, Calvano, JE, Hahm, SJ, Coyle, SM, Corbett, SA, Calvano, SE, Lowry, SF (2002) Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections. J Infect Dis 186: pp. 1522-1525 CrossRef
11. Akira, S, Takeda, K, Kaisho, T (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2: pp. 675-680 CrossRef
12. Werling, D, Jungi, TW (2003) TOLL-like receptors linking innate and adaptive immune response. Vet Immunol Immunopathol 91: pp. 1-12 CrossRef
13. Kang, SS, Kauls, LS, Gaspari, AA (2006) Toll-like receptors: applications to dermatologic disease. J Am Acad Dermatol 54: pp. 951-983 CrossRef
14. Arancibia, SA, Beltran, CJ, Aguirre, IM, Silva, P, Peralta, AL, Malinarich, F, Hermoso, MA (2007) Toll-like receptors are key participants in innate immune responses. Biol Res 40: pp. 97-112 CrossRef
15. Yang, H, Wei, C, Li, Q, Shou, T, Yang, Y, Xiao, C, Yu, M, Li, M, Yang, Z, Zhang, J, Zheng, B (2013) Association of TLR4 gene non-missense single nucleotide polymorphisms with rheumatoid arthritis in Chinese Han population. Rheumatol Int 33: pp. 1283-1288 CrossRef
16. Aderem, A, Ulevitch, RJ (2000) Toll-like receptors in the induction of the innate immune response. Nature 406: pp. 782-787
文摘
Background Sepsis is now the leading cause of death in the non-cardiovascular intensive care unit (ICU). Recent research suggests that sepsis is likely to be due to an interaction between genetic and environmental factors. Genetic mutations of toll-like receptor 4 (TLR4) and cluster of differentiation 14 (CD14) genes are involved in the immune and (or) inflammatory response. These may contribute to the susceptibility to sepsis in patients. This study was designed to evaluate whether the TLR4 and cluster CD14 gene polymorphisms are associated with susceptibility to sepsis. Methods The single nucleotide polymorphisms (SNPs) of TLR4 (rs10759932, rs11536889, rs7873784, rs12377632, rs1927907, rs1153879) and CD14 (rs2569190 and rs2563298) in patients with sepsis and control subjects in the Guangxi Province were analyzed by using the polymerase chain reaction-single base extension (PCR-SBE) and DNA sequencing methods. Results The rs11536889 polymorphism in TLR4 and rs2563298 polymorphism in CD14 were significantly associated with the risk of sepsis when compared to the control group. The frequencies of rs11536889 and rs2563298 polymorphisms in the group with sepsis were higher than that in the control group (OR--.430, 95% CI, 1.032-1.981, P0.05; OR--.454, 95% CI, 1.458-4.130, P Conclusions The rs11536889 polymorphism in TLR4 and rs2563298 polymorphism in CD14, and two haplotypes were associated with increased susceptibility to sepsis.