CD14 and IL6 polymorphisms are associated with a pro-atherogenic profile in young adults with acute myocardial infarction
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- 作者：Lidio Gon?alves Lima-Neto…
- 关键词：CD14 ; IL ; 6 ; TLR4 ; Gene polymorphism ; Myocardial infarction
- 刊名：Journal of Thrombosis and Thrombolysis
- 出版年：2013
- 出版时间：October 2013
- 年：2013
- 卷：36
- 期：3
- 页码：332-340
- 全文大小：219KB
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Rosario Dominguez Crespo Hirata (1)
André Ducati Luchessi (1)
Vivian Nogueira Silbiger (1)
Marco Antonio Stephano (2)
Marcelo Ferraz Sampaio (3)
Dikran Armaganijan (3)
Mario Hiroyuki Hirata (1)
1. Department of Clinical Analysis and Toxicology, Faculdade de Ciencias Farmaceuticas, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 580, B.17, S?o Paulo, SP, 05508900, Brazil
2. Department of Pharmaceutical Technology, School of Pharmaceutical Sciences, University of Sao Paulo, S?o Paulo, SP, Brazil
3. Institute Dante Pazzanese of Cardiology, S?o Paulo, SP, Brazil - ISSN：1573-742X
文摘
This study investigated the relationship of polymorphisms in genes encoding CD14, IL-6 and TLR4 with metabolic, inflammatory and endothelial markers in young adults with acute myocardial infarction (AMI). Glucose, lipids, nitrate and inflammatory markers, flow mediated vasodilatation (FMV) and flow mediated by nitrate (FMN) were evaluated in 102 AMI and 108 non-AMI (control group) young individuals (<45?years). CD14 ?60C>T (rs2569190), IL6 ?74G>C (rs1800795) and TLR4 c.896A>G (rs4986790) and TLR4 c.1196C>T (rs4986791) polymorphisms were analyzed by PCR–RFLP. Minor allele frequencies of CD14, IL6 and TLR4 polymorphisms were similar between AMI and control groups (p?>?0.05). In AMI group, individuals carrying IL6 ?74CC genotype had higher serum triglycerides, VLDL cholesterol and glucose compared to the IL6 ?74GG/GC genotype carriers (p?<?0.05). Multiple logistic analysis showed that IL6 ?74CC genotype carriers had increased risk for hyperglycemia (>5.77?mmol/l) [OR: 6.75, 95?% CI: 1.80-4.40, p?=?0.004] and hypertriglyceridemia (>2.68?mmol/l) [OR: 3.00, 95?% CI: 1.00-.00, p?=?0.043]. Moreover, CD14 ?60TT genotype was associated with reduced serum HDL cholesterol [OR: 3.10, 95?% CI: 1.00-.01, p?=?0.044] and apolipoprotein AI [OR: 3.20, 95?% CI: 1.00-.70, p?=?0.038] in AMI group. Relationship between CD14 and IL6 variants and altered inflammatory and endothelial (nitrate, FMV and FMN) markers was not found in both AMI and control groups. The IL6 ?74G>C and CD14 ?60C>T polymorphisms are likely to be associated with a pro-atherogenic profile but not with increased inflammatory markers and endothelial dysfunction in young AMI patients.