Modulating crossover positioning by introducing large structural changes in chromosomes

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• 作者：Antoine Ederveen (1)
  Yuching Lai (2) (3)
  Marc A van Driel (2) (4)
  Tom Gerats (1)
  Janny L Peters (1)
  
  1. Department of Molecular Plant Physiology ; Radboud University Nijmegen ; Institute for Water and Wetland Research (IWWR) ; Heyendaalseweg 135 ; 6525 AJ ; Nijmegen ; The Netherlands
  2. Netherlands Bioinformatics Centre ; 260 NBIC ; P.O. Box 9101 ; 6500 HB ; Nijmegen ; The Netherlands
  3. The Delft Bioinformatics Lab ; Department of Intelligent Systems ; Delft University of Technology ; Mekelweg 4 ; 2628 CD ; Delft ; The Netherlands
  4. Current affiliation ; Philips Research ; High Tech Campus 11 ; 5656 AE ; Eindhoven ; The Netherlands
  
• 关键词：Arabidopsis thaliana ; Meiosis ; Crossover positioning ; Recombination frequency ; Chromosome modifications ; Deletion ; Inversion ; Gamma ; irradiation
• 刊名：BMC Genomics
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：16
• 期：1
• 全文大小：1,064 KB
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• 刊物主题：Life Sciences, general; Microarrays; Proteomics; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics;
• 出版者：BioMed Central
• ISSN：1471-2164

文摘

Background Crossing over assures the correct segregation of the homologous chromosomes to both poles of the dividing meiocyte. This exchange of DNA creates new allelic combinations thus increasing the genetic variation present in offspring. Crossovers are not uniformly distributed along chromosomes; rather there are preferred locations where they may take place. The positioning of crossovers is known to be influenced by both exogenous and endogenous factors as well as structural features inherent to the chromosome itself. We have introduced large structural changes into Arabidopsis chromosomes and report their effects on crossover positioning. Results The introduction of large deletions and putative inversions silenced recombination over the length of the structural change. In the majority of cases analyzed, the total recombination frequency over the chromosomes was unchanged. The loss of crossovers at the sites of structural change was compensated for by increases in recombination frequencies elsewhere on the chromosomes, mostly in single intervals of one to three megabases in size. Interestingly, two independent cases of induced structural changes in the same chromosomal interval were found on both chromosomes 1 and 2. In both cases, compensatory increases in recombination frequencies were of similar strength and took place in the same chromosome region. In contrast, deletions in chromosome arms carrying the nucleolar organizing region did not change recombination frequencies in the remainder of those chromosomes. Conclusions When taken together, these observations show that changes in the physical structure of the chromosome can have large effects on the positioning of COs within that chromosome. Moreover, different reactions to induced structural changes are observed between and within chromosomes. However, the similarity in reaction observed when looking at chromosomes carrying similar changes suggests a direct causal relation between induced change and observed reaction.