Genome wide in silico analysis of Plasmodium falciparum phosphatome
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- 作者：Rajan Pandey (14)
Asif Mohmmed (15)
Christine Pierrot (16)
Jamal Khalife (16)
Pawan Malhotra (15)
Dinesh Gupta (14)
14. Structural and Computational Biology group ; International Centre for Genetic Engineering and Biotechnology ; Aruna Asaf Ali Marg ; New Delhi ; 110067 ; India
15. Malaria Group ; International Centre for Genetic Engineering and Biotechnology ; Aruna Asaf Ali Marg ; New Delhi ; 110067 ; India
16. Center for Infection and Immunity of Lille ; Inserm U1019 ; CNRS ; Institut Pasteur de Lille ; Univ Lille Nord de France ; 1 rue du Professeur Calmette ; Lille cedex ; 59019 ; France - 关键词：Posttranslational modifications ; PTM ; PFAM ; CDD ; Phosphatome ; Phosphatase ; Dephosphorylation
- 刊名：BMC Genomics
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：15
- 期：1
- 全文大小：1,111 KB
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- 出版者：BioMed Central
- ISSN：1471-2164
文摘
Background Eukaryotic cellular machineries are intricately regulated by several molecular mechanisms involving transcriptional control, post-translational control and post-translational modifications of proteins (PTMs). Reversible protein phosphorylation/dephosphorylation process, which involves kinases as well as phosphatases, represents an important regulatory mechanism for diverse pathways and systems in all organisms including human malaria parasite, Plasmodium falciparum. Earlier analysis on P. falciparum protein-phosphatome revealed presence of 34 phosphatases in Plasmodium genome. Recently, we re-analysed P. falciparum phosphatome aimed at identifying parasite specific phosphatases. Results Plasmodium database (PlasmoDB 9.2) search, combined with PFAM and CDD searches, revealed 67 candidate phosphatases in P. falciparum. While this number is far less than the number of phosphatases present in Homo sapiens, it is almost the same as in other Plasmodium species. These Plasmodium phosphatase proteins were classified into 13 super families based on NCBI CDD search. Analysis of proteins expression profiles of the 67 phosphatases revealed that 44 phosphatases are expressed in both schizont as well as gametocytes stages. Fourteen phosphatases are common in schizont, ring and trophozoite stages, four phosphatases are restricted to gametocytes, whereas another three restricted to schizont stage. The phylogenetic trees for each of the known phosphatase super families reveal a considerable phylogenetic closeness amongst apicomplexan organisms and a considerable phylogenetic distance with other eukaryotic model organisms included in the study. The GO assignments and predicted interaction partners of the parasite phosphatases indicate its important role in diverse cellular processes. Conclusion In the study presented here, we reviewed the P. falciparum phosphatome to show presence of 67 candidate phosphatases in P. falciparum genomes/proteomes. Intriguingly, amongst these phosphatases, we could identify six Plasmodium specific phosphatases and 33 putative phosphatases that do not have human orthologs, thereby suggesting that these phosphatases have the potential to be explored as novel antimalarial drug targets.