Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia

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• 作者：S. Kittel-Schneider (1) (6)
  T. Wobrock (2) (3)
  H. Scherk (2) (4)
  T. Schneider-Axmann (5)
  S. Trost (2)
  D. Zilles (2)
  C. Wolf (2)
  A. Schmitt (5) (7)
  B. Malchow (5)
  A. Hasan (5)
  M. Backens (8)
  W. Reith (8)
  P. Falkai (5)
  O. Gruber (2)
  A. Reif (1) (6)
  
  1. Psychiatric Neurobiology and Bipolar Disorder Program ; Department of Psychiatry ; Psychosomatics and Psychotherapy ; University of W眉rzburg ; F眉chsleinstr. 15 ; 97080 ; W眉rzburg ; Germany
  6. Comprehensive Heart Failure Center ; University of W眉rzburg ; 97078 ; W眉rzburg ; Germany
  2. Department of Psychiatry and Psychotherapy ; University of G枚ttingen ; von-Siebold-Str. 5 ; 37075 ; G枚ttingen ; Germany
  3. Centre of Mental Health ; Darmstadt-Dieburg Clinics ; 64823 ; Gro脽-Umstadt ; Germany
  4. AMEOS Klinikum Osnabr眉ck ; 49088 ; Osnabr眉ck ; Germany
  5. Department of Psychiatry and Psychotherapy ; LMU Munich ; Nu脽baumstrasse 7 ; 80336 ; Munich ; Germany
  7. Laboratory of Neuroscience (LIM27) ; Institute of Psychiatry ; University of Sao Paulo ; Rua Dr. Ovidio Pires de Campos 785 ; S茫o Paulo ; SP ; 05453-010 ; Brazil
  8. Department of Neuroradiology ; University of Saarland ; 66421 ; Homburg/Saar ; Germany
  
• 关键词：DGKH ; Bipolar disorder ; Schizophrenia ; Amygdala ; Structural MRI
• 刊名：European Archives of Psychiatry and Clinical Neuroscience
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：265
• 期：2
• 页码：127-136
• 全文大小：300 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Psychiatry
  Neurosciences
  Neurology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-8491

文摘

The diacylglycerol kinase eta (DGKH) gene, first identified in a genome-wide association study, is one of the few replicated risk genes of bipolar affective disorder (BD). Following initial positive studies, it not only was found to be associated with BD but also implicated in the etiology of other psychiatric disorders featuring affective symptoms, rendering DGKH a cross-disorder risk gene. However, the (patho-)physiological role of the encoded enzyme is still elusive. In the present study, we investigated primarily the influence of a risk haplotype on amygdala volume in patients suffering from schizophrenia or BD as well as healthy controls and four single nucleotide polymorphisms conveying risk. There was a significant association of the DGKH risk haplotype with increased amygdala volume in BD, but not in schizophrenia or healthy controls. These findings add to the notion of a role of DGKH in the pathogenesis of BD.