Immune tolerance induced by intravenous transfer of immature dendritic cells via up-regulating numbers of suppressive IL-10+ IFN-γ+-producing CD4+ T cells

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• 作者：Fang Zhou (1)
  Bogoljub Ciric (1)
  Guang-Xian Zhang (1)
  Abdolmohamad Rostami (1)
  
• 关键词：Dendritic cell ; EAE ; Immune tolerance ; Autoimmunity
• 刊名：Immunologic Research
• 出版年：2013
• 出版时间：May 2013
• 年：2013
• 卷：56
• 期：1
• 页码：1-8
• 全文大小：496KB
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• 作者单位：Fang Zhou (1)
  Bogoljub Ciric (1)
  Guang-Xian Zhang (1)
  Abdolmohamad Rostami (1)
  
  1. Department of Neurology, Thomas Jefferson University, 900 Walnut Street, Philadelphia, PA, 19107, USA
  

文摘

Dendritic cells (DCs) regulate immunity and immune tolerance in vivo. However, the mechanisms of DC-mediated tolerance have not been fully elucidated. Here, we demonstrate that intravenous (i.v.) transfer of bone marrow-derived DCs pulsed with myelin oligodendrocyte glycoprotein (MOG) peptide blocks the development of experimental autoimmune encephalomyelitis in C57BL/6J mice. i.v. transfer of MOG-pulsed DCs leads to the down-regulation of the production of IL-17A and IFN-γ and up-regulation of IL-10 secretion. The development of regulatory T cells (Tregs) is facilitated via up-regulation of FoxP3 expression and production of IL-10. The number of suppressive CD4+IL-10+IFN-γ+ T cells is also improved. The expression of OX40, CD154, and CD28 is down-regulated, but the expression of CD152, CD80, PD-1, ICOS, and BTLA is up-regulated on CD4+ T cells after i.v. transfer of immature DCs. The expression of CCR4, CCR5, and CCR7 on CD4+ T cells is also improved. Our results suggest that immature DCs may induce tolerance via facilitating the development of CD4+FoxP3+ Tregs and suppressive CD4+IL-10+IFN-γ+ T cells in vivo.