Apoptotic cell-treated dendritic cells induce immune tolerance by specifically inhibiting development of CD4+ effector memory T cells

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• 作者：Fang Zhou ; Guang-Xian Zhang ; Abdolmohamad Rostami
• 关键词：Dendritic cell ; Immune tolerance ; Immunotherapy ; Memory T cell ; Autoimmunity ; Inflammation ; Apoptosis
• 刊名：Immunologic Research
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：64
• 期：1
• 页码：73-81
• 全文大小：1,630 KB
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• 作者单位：Fang Zhou (1) (2)
  Guang-Xian Zhang (1)
  Abdolmohamad Rostami (1)
  
  1. Department of Neurology, Thomas Jefferson University, 901 Walnut Street, Philadelphia, PA, 19107, USA
  2. Laboratory of Liver Cancer Immunotherapy, Greenslopes Private Hospital, School of Medicine, University of Queensland, Greenslopes, Brisbane, QLD, 4120, Australia
  
• 刊物主题：Allergology; Immunology; Medicine/Public Health, general; Internal Medicine;
• 出版者：Springer US
• ISSN：1559-0755

文摘

CD4+ memory T cells play an important role in induction of autoimmunity and chronic inflammatory responses; however, regulatory mechanisms of CD4+ memory T cell-mediated inflammatory responses are poorly understood. Here we show that apoptotic cell-treated dendritic cells inhibit development and differentiation of CD4+ effector memory T cells in vitro and in vivo. Simultaneously, intravenous transfer of apoptotic T cell-induced tolerogenic dendritic cells can block development of experimental autoimmune encephalomyelitis (EAE), an inflammatory disease of the central nervous system in C57 BL/6J mouse. Our results imply that it is effector memory CD4+ T cells, not central memory CD4+ T cells, which play a major role in chronic inflammatory responses in mice with EAE. Intravenous transfer of tolerogenic dendritic cells induced by apoptotic T cells leads to immune tolerance by specifically blocking development of CD4+ effector memory T cells compared with results of EAE control mice. These results reveal a new mechanism of apoptotic cell-treated dendritic cell-mediated immune tolerance in vivo. Keywords Dendritic cell Immune tolerance Immunotherapy Memory T cell Autoimmunity Inflammation Apoptosis