Adipocytokines and liver fibrosis stages in patients with chronic hepatitis B virus infection

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• 作者：Ching-Sheng Hsu ; Wei-Liang Liu ; You-Chen Chao…
• 关键词：Hepatitis B virus ; Adipocytokine ; HBsAg ; Chronic hepatitis B ; HBV DNA ; Liver fibrosis
• 刊名：Hepatology International
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：9
• 期：2
• 页码：231-242
• 全文大小：256 KB
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• 刊物主题：Hepatology; Colorectal Surgery; Surgery;
• 出版者：Springer India
• ISSN：1936-0541

文摘

Background Adipocytokines play an important role in lipid metabolism and liver disease progression. However, the interactions between hepatitis B virus (HBV) infection and adipocytokines remain largely unknown. Aims To investigate the association of HBV infection with adipocytokines in HBV-infected and noninfected subjects. In addition, the impact of adipocytokines on serum HBV DNA, HBsAg levels and liver fibrosis stage was also examined. Methods A case-control analysis of patients with and without chronic HBV infection was performed. The HBV group consisted of 187 patients with chronic HBV infection, and the control group consisted of 184 age-, gender- and body mass index-matched subjects without HBV infection. Fasting blood glucose, lipid profiles, adiponectin, leptin and visfatin levels were compared between the two groups. APRI and FIB-4 were calculated to estimate the severity of liver fibrosis. Results Most of the enrolled subjects had lower ALT levels [228 (57.7?%) ALT?p?p? Conclusions Patients with chronic HBV infection have significantly higher serum adiponectin and visfatin but lower leptin levels than healthy controls. Serum adipocytokine levels independently correlate with HBV viremia, HBsAg levels and liver fibrosis stages.