The role of adipocytokines in the pathogenesis of knee joint osteoarthritis
详细信息 查看全文
- 作者：Magdalena Richter ; Tomasz Trzeciak ; Maciej Owecki…
- 关键词：Osteoarthritis ; Adipocytokines ; Obesity ; Adipose tissue
- 刊名：International Orthopaedics
- 出版年：2015
- 出版时间：June 2015
- 年：2015
- 卷：39
- 期：6
- 页码：1211-1217
- 全文大小：229 KB
- 参考文献：1.Garner M, Alshameeri Z, Khanduja V (2013) Osteoarthritis: genes, nature-nurture interaction and the role of leptin. Int Orthop 37:2499鈥?505. doi:10.鈥?007/鈥媠00264-013-2088-x PubMed Central PubMed View Article
2.Blagojevic M, Jinks C, Jeffery A, Jordan KP (2010) Risk factors for onset of osteoarthritis in older adults: a systematic review and meta-analysis. Osteoarthr Cartil 18:24鈥?3. doi:10.鈥?016/鈥媕.鈥媕oca.鈥?009.鈥?8.鈥?10 PubMed View Article
3.Houard X, Goldring MB, Berenbaum F (2013) Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis. Curr Rhematol Rep 15:375. doi:10.鈥?007/鈥媠11926-013-0375-6 View Article
4.Zhang Y, Jordan JM (2010) Epidemiology of osteoarthritis. Clin Geriatr Med 26:355鈥?69. doi:10.鈥?016/鈥媕.鈥媍ger.鈥?010.鈥?3.鈥?01 PubMed Central PubMed View Article
5.Pottie P, Presle N, Terlain B, Netter P, Mainard D, Berenbaum F (2006) Obesity and osteoarthritis: more complex than predicted. Ann Rheum Dis 65:1403e5. doi:10.鈥?136/鈥媋rd.鈥?006.鈥?61994 View Article
6.Grotle M, Hagen KB, Natvig B, Dahl FA, Kvien TK (2008) Obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 years follow-up. BMC Musculoskelet Disord 9:132. doi:10.鈥?186/鈥?471-2474-9-132 PubMed Central PubMed View Article
7.Berenbaum F (2013) Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthr Cartil 21:16鈥?1. doi:10.鈥?016/鈥媕.鈥媕oca.鈥?012.鈥?1.鈥?12 PubMed View Article
8.Felson DT (2013) Osteoarthritis as a disease of mechanics. Osteoarthritis Cartilage 21:10鈥?5. doi:10.鈥?016/鈥媕.鈥媕oca.鈥?012.鈥?9.鈥?12 PubMed View Article
9.De Boer TN, van Spil WE, Huisman AM, Polak AA, Bijlsma JWJ, Lafeber FPJG, Mastbergen SC (2012) Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage. Osteoarthr Cartil 20:846鈥?53. doi:10.鈥?016/鈥媕.鈥媕oca.鈥?012.鈥?5.鈥?02 PubMed View Article
10.Migliaccio S, Greco EA, Wannenes F, Donini LM, Lenzi A (2014) Adipose, bone and muscle tissues as new endocrine organs: role of reciprocal regulation for osteoporosis and obesity development. Horm Mol Biol Clin Invest 17:39鈥?1. doi:10.鈥?515/鈥媓mbci-2013-0070
11.Thomas T, Gori F, Khosla S, Jensen MD, Burguera B, Riggs BL (1999) Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology 140:1630鈥?638. doi:10.鈥?210/鈥媏ndo.鈥?40.鈥?.鈥?637 PubMed
12.Cornish J, Callon KE, Bava U, Lin C, Naot D, Hill BL, Grey AB, Broom N, Myers DE, Nicholson GC, Reid IR (2002) Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo. J Endocrinol 175:405鈥?15PubMed View Article
13.Matsuzawa Y (2006) Therapy insight: adipocytokines in metabolic syndrome and related cardiovascular disease. Nat Clin Pract Cardiovasc Med 3(1):35鈥?2. doi:10.鈥?038/鈥媙cpcardio0380 PubMed View Article
14.Abella V, Scotece M, Conde J, Lopez V, Lazzaro V, Pino J, Gomez-Reino JJ, Gualillo O (2014) Adipokines, metabolic syndrome and rheumatic diseases. J Immunol Res ID 343746. doi:10.鈥?155/鈥?014/鈥?43746
15.Scotece M, Conde J, G贸mez R, L贸pez V, Lago F, G贸mez-Reino JJ (2011) Beyond fat mass: exploring the role of adipokines in rheumatic disease. Sci World J 11:1932鈥?947. doi:10.鈥?100/鈥?011/鈥?90142 View Article
16.Hu PF, Tang JL, Chen WP, Bao JP, Wu LD (2011) Increased apelin serum levels and expression in human chondrocytes in osteoarthritis patients. Int Orthop 35:1421鈥?426. doi:10.鈥?007/鈥媠00264-010-1100-y PubMed Central PubMed View Article
17.L眉bbeke A, Finckh A, Puskas GJ, Suva D, L盲dermann A, Bas S, Fritschy D, Gabay C, Hoffmeyer P (2013) Do synovial leptin levels correlate with pain in end stage arthritis? Int Orthop 37:2071鈥?079. doi:10.鈥?007/鈥媠00264-013-1982-6 PubMed Central PubMed View Article
18.Vuolteenaho K, Koskinen A, Moilanen E (2014) Leptin- a link between obesity and osteoarthritis. Applications for prevention and treatment. Basic Clin Pharmacol Toxicol:103鈥?08. doi:10.鈥?111/鈥媌cpt.鈥?2160
19.Clockaerts S, Bastiaansen-Jenniskens YM, Runhaar J, Van Osch GJVM, Van Offel JF, Verhaar JAN, De Clerck LS, Somville J (2010) The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review. Osteoatrhr Cartil 18:876鈥?82. doi:10.鈥?016/鈥媕.鈥媕oca.鈥?010.鈥?3.鈥?14 View Article
20.Hui W, Litherland J, Elias MS, Kitson GI, Cawston TE, Rowan AD, Young DA (2012) Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases. Ann Rheum Dis 71:455鈥?62. doi:10.鈥?136/鈥媋nnrheumdis-2011-200372 PubMed View Article
21.Koskinen A, Juslin S, Nieminen R, Moilanen T, Vuolteenaho K, Moilanen E (2011) Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways. Arthr Res Ther 13:R184. doi:10.鈥?186/鈥媋r3512 View Article
22.Presle N, Pottie P, Dumond H, Guillame C, Lapicque F, Pallu S, Mainard D, Netter P, Terlain B (2006) Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tisues to their articular production. Osteoarthr Cartil 14:690鈥?95. doi:10.鈥?016/鈥媕.鈥媕oca.鈥?006.鈥?1.鈥?09 PubMed View Article
23.Zhang Y, Proenca R, Maffei M, Barone M, Loepold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425鈥?32. doi:10.鈥?038/鈥?72425a0 PubMed View Article
24.Meier U, Gressner AM (2004) Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, Ghrelin, adiponectin and resistin. Clin Chem 50:1511鈥?525. doi:10.鈥?373/鈥媍linchem.鈥?004.鈥?32482 PubMed View Article
25.Koerner A, Kratzsch J, Kiess W (2005) Adipocytokines: leptin- the classical, resistin- the controversical, adiponectin- the promising, and more to come. Best Prac Res Clin Endocrinol Metab 19(4):525鈥?46. doi:10.鈥?016/鈥媕.鈥媌eem.鈥?005.鈥?7.鈥?08 View Article
26.Rasouli N, Kern FA (2008) Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab 93:64鈥?3. doi:10.鈥?210/鈥媕c.鈥?008-1613 View Article
27.Jasi艅ska A, Pietruczuk M (2010) Adipocytokiny bia艂ka o wielokierunkowym dzia艂aniu. J Lab Diagn 46(3):331鈥?38
28.Saad MF, Damani S, Gingerich RL, Riad-Gabriel MG, Khan A, Boyadjian R, Jinagouda SD, el-Tawil K, Rude RK, Kamdar V (1997) Sexual dimorphism in plasma leptin concentration. J Clin Endocrinol Metab 82(2):579鈥?84PubMed
29.Horlick MB, Rosenbaum M, Nicolson M, Levine LS, Fedun B, Wang J, Pierson RN Jr, Leibel RL (2000) Effect of puberty on the relationship between circulating leptin and body composition. J Clin Endocrinol Metab 85(7):2509鈥?518PubMed
30.Ashima RS, Lazar MA (2008) Adipocytokines and the peripheral and neutral control of energy balance. Mol Endocrinol 22(5):1023鈥?031. doi:10.鈥?210/鈥媘e.鈥?007-0529 View Article
31.Fern谩ndez-Riejos P, Najib S, Santos-Alvarez J, Mart铆n-Romero C, P茅rez-P茅rez A, Gonz谩lez-Yanes C, Sanchez-Margalet V (2010) Role of leptin in the activation of immune cells. Mediators Inflamm 568343. doi:10.鈥?155/鈥?010/鈥?68343
32.Yang RZ, Huang Q, Xu A, McLenithan JC, Eisen JA, Shuldiner AR, Alkan S, Gong DW (2003) Comparative studies of resistin expression and phylogenomics in human and mouse. Biochem Biophys Res Commun 310(3):927鈥?35. doi:10.鈥?016/鈥媕.鈥媌brc.鈥?003.鈥?9.鈥?93 PubMed View Article
33.Wulster-Radcliffe MC, Ajuwon KM, Wang J, Christian JA, Spurlock ME (2004) Adiponectin differentially regulates cytokines in porcine macrophages. Biochem Biophys Res Commun 316(3):924鈥?29. doi:10.鈥?016/鈥媕.鈥媌brc.鈥?004.鈥?2.鈥?30 PubMed View Article
34.Milan G, Granzotto M, Scarda A, Calcagno A, Pagano C, Federspil G, Vettor R (2002) Resistin and adiponectin expression in visceral fat of obese rats: effect of weight loss. Obes Res 10(11):1095鈥?103PubMed View Article
35.Silswal N, Singh AK, Aruna B, Mukhopadhyay S, Ghosh S, Ehtesham NZ (2005) Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway. Biochem Biophys Res Commun 334(4):1092鈥?101. doi:10.鈥?016/鈥媕.鈥媌brc.鈥?005.鈥?6.鈥?02 PubMed View Article
36.Bokarewa M, Nagaey I, Dahlberg L, Smith U, Tarkowski A (2005) Resistin, an adipokine with potent proinflammatory properties. J Immunol 174(9):5789鈥?795. doi:10.鈥?049/鈥?jimmunol.鈥?74.鈥?.鈥?789 PubMed View Article
37.Verma S, Li SH, Wang CH, Fedak PW, Li RK, Weisel RD, Mickle DA (2003) Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction. Circulation 108(6):736鈥?40. doi:10.鈥?161/鈥?1.鈥婥IR.鈥?000084503.鈥?1330.鈥?9 PubMed View Article
38.Kang EH, Lee YL, Kim TK, Chang CB, Chung J-H, Shin K, Lee EY, Lee EB, Song YW (2010) Adiponectin is a potential catabolic mediator in osteoarthritis cartilage. Arthr Res Ther 12(6):R231. doi:10.鈥?186/鈥媋r3218 View Article
39.Hu P, Bao J, Wu L (2011) The emerging role of adipokines in osteoarthritis: a narrative review. Mol Biol Rep 38(2):873鈥?78. doi:10.鈥?007/鈥媠11033-010-0179-y PubMed View Article
40.Lago R, Gomez R, Otero M, Lago F, Gallego R, Dieguez C, Gomez-Reino JJ, Gualillo O (2008) A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes. Osteoarthr Cartil 16(9):1101鈥?109. doi:10.鈥?016/鈥媕.鈥媕oca.鈥?007.鈥?2.鈥?08 PubMed View Article
41.Skoczylas A (2009) The role of visfatin in the pathophysiology of human. Wiad Lek 62(3):190鈥?96PubMed
42.Samal B, Sun Y, Stearns G, Xie C, Suggs S, McNiece I (1994) Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol 14(2):1431鈥?437. doi:10.鈥?128/鈥婱CB.鈥?4.鈥?.鈥?431 PubMed Central PubMed
43.Versini M, Jeandel PY, Rosenthal E, Shoenfeld Y (2014) Obesity in autoimmune diseases: not a passive bystander. Autoimmun Rev 13(9):981鈥?000. doi:10.鈥?016/鈥媕.鈥媋utrev.鈥?014.鈥?7.鈥?01 PubMed View Article
44.Friebe D, Neef M, Kratzsch J, Erbs S, Dittrich K, Garten A, Petzold-Quinque S, Bluhler S, Reinehr T, Stumvoll M, Bluher M, Kiess W, Korner A (2011) Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans. Diabetologia 54(5):1200鈥?211. doi:10.鈥?007/鈥媠00125-010-2042-z PubMed Central PubMed View Article
45.Catalan V, Gomez-Ambrosi J, Rodriguez A, Ramirez B, Silva C, Rotellar F, Cienfuegos JA, Fruhbeck G (2011) Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity. Nutr Metab Cardiovasc Dis 21(4):245鈥?53. doi:10.鈥?016/鈥媕.鈥媙umecd.鈥?009.鈥?9.鈥?08 PubMed
46.Bao JP, Chen WP, Feng J, Hu PF, Shi ZL, Wu LD (2010) Leptin plays a catabolic role on articular cartilage. Mol Biol Rep 37(7):3265鈥?272. doi:10.鈥?007/鈥媠11033-009-9911-x PubMed View Article
47.Choi S-E, Fu T, Seok S, Kim D-H, Yu E, Lee K-W, Kang Y, Li X, Kemper JK (2013) Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. Aging Cell 12(6):1062鈥?072. doi:10.鈥?111/鈥媋cel.鈥?2135 PubMed View Article
48.Sch盲ffler A, Neumeier M, Herfarth H, F眉rst A, Sch枚lmerich J, B眉chler C (2005) Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue. Biochim Biophys Acta 1732(1鈥?):96鈥?02. doi:10.鈥?016/鈥媕.鈥媌baexp.鈥?005.鈥?1.鈥?05 PubMed View Article
49.Yang RZ, Lee MJ, Hu H, Pray J, Wu HB, Hansen BC, Shuldiner AR, Sk F, McLenithan JC, Gong DW (2006) Identification of omentin as a novel depot- specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab 290(6):E1253鈥揈1261. doi:10.鈥?152/鈥媋jpendo.鈥?0572.鈥?004 PubMed View Article
50.De Souza Batista CM, Yang RZ, Lee MJ, Glynn NM, Yu DZ, Pray J, Ndubuizu K, Patil S, Schwartz A, Kligman M, Fried SK, Gong DW, Shuldiner AR, Pollin TI, McLenithan JC (2007) Omentin plasma levels and gene expression are decreased in obesity. Diabetes 56(6):1655鈥?661. doi:10.鈥?337/鈥媎b06-1506 PubMed View Article
51.Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A et al (2005) Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. PNAS 102(30):10610鈥?0615. doi:10.鈥?073/鈥媝nas.鈥?504703102 PubMed Central PubMed View Article
52.Fantuzzi G (2005) Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 115(5):911鈥?19. doi:10.鈥?016/鈥媕.鈥媕aci.鈥?005.鈥?2.鈥?23 PubMed View Article
53.Tilg H, Moschen AR (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6(10):772鈥?83. doi:10.鈥?038/鈥媙ri1937 PubMed View Article
54.Cianflone K, Xia Z, Chen LY (2003) Critical review of acylation-stimulating protein physiology in humans and rodents. Biochim Biophys Acta 1609(2):127鈥?43. doi:10.鈥?016/鈥婼0005-2736(02)00686-7 PubMed View Article
55.Dumond H, Presle N, Terlain B, Mainard D, Loeuille D, Netter P, Pottie P (2003) Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum 48(11):3118鈥?129. doi:10.鈥?002/鈥媋rt.鈥?1303 PubMed View Article
56.Yaykasli KO, Hatipoglu OF, Yaykasli E, Yildirim K, Kaya E, Ozsahin M, Uslu M, Gunduz E (2014) Leptin induces ADAMTS-4, ADAMTS-5, and ADAMTS-9 genes expression by mitogen-activated protein kinases and NF-母B signaling pathways in human chondrocytes. Cell Biol Int. doi:10.鈥?002/鈥媍bin.鈥?0336 PubMed
57.Vuolteenaho K, Koskinen A, Kukkonen M, Nieminen R, P盲iv盲rinta U, Moilanen T, Moilanen E (2009) Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage鈥攎ediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production. Mediators Inflamm 2009:345838. doi:10.鈥?155/鈥?009/鈥?45838
58.Berry PA, Jones SW, Cicuttini FM, Wluka AE, Maciewicz RA (2011) Temporal relationship between serum adipokines, biomarkers of bone and cartilage turnover, and cartilage volume loss in a population with clinical knee osteoarthritis. Arthritis Rheum 63:700鈥?07. doi:10.鈥?002/鈥媋rt.鈥?0182 PubMed View Article
59.Francin PJ, Abot A, Guillaume C, Moulin D, Bianchi A, Gegout-Pottie P, Jouzeau JY, Mainard D, Presle N (2014) Association between adiponectin and cartilage degradation in human osteoarthritis. Osteoarthr Cartil 22:519鈥?26. doi:10.鈥?016/鈥媕.鈥媕oca.鈥?014.鈥?1.鈥?02 PubMed View Article
60.Chen TH, Chen L, Hsieh MS, Chang CP, Chou DT, Tsai SH (2006) Evidence for a protective role for adiponectin in osteoarthritis. Biochim Biophys Acta 1762:711鈥?18. doi:10.鈥?016/鈥媕.鈥媌badis.鈥?006.鈥?6.鈥?08 PubMed View Article
61.Gosset M, Berenbaum F, Salvat C, Sautet A, Pigenet A, Tahiri K, Jacques C (2008) Crucial role of visfatin/pre-B cell colonyenhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis. Arthritis Rheum 58:1399鈥?409. doi:10.鈥?002/鈥媋rt.鈥?3431 PubMed View Article
62.Yammani RR, Loeser RF (2012) Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin- like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes. Arthritis Res Ther 14:R23. doi:10.鈥?186/鈥媋r3705 PubMed Central PubMed View Article
63.Hong EH, Yun HS, Kim J, Um HD, Lee KH, Kang CM, Lee SJ, Chun JS, Hwang SG (2011) Nicotinamide phosphoribosyltransferase is essential for interleukin-1beta-mediated dedifferentiation of articular chondrocytes via SIRT1 and extracellular signal-regulated kinase (ERK) complex signaling. J Biol Chem 286:28619鈥?8631. doi:10.鈥?074/鈥媕bc.鈥婱111.鈥?19832 PubMed Central PubMed View Article
64.Duan Y, Hao D, Li M, Wu Z, Li D, Yang X, Qiu G (2012) Increased synovial fluid visfatin is positively linked to cartilage degradation biomarkers in osteoarthritis. Rheumatol Int 32:985鈥?90. doi:10.鈥?007/鈥媠00296-010-1731-8 PubMed View Article
65.Laiguillon MC, Houard X, Bougault C, Gosset M, Nourissat G, Sautet A, Jacques C, Berenbaum F, Sellam J (2014) Expression and function of visfatin (Nampt), an adipokine-enzyme involved in inflammatory pathways of osteoarthritis. Arthritis Res Ther 16:R38. doi:10.鈥?186/鈥媋r4467 PubMed Central PubMed View Article
66.Gilbertson EM (1975) Development of periarticular osteophytes in experimentally induced osteoarthritis in the dog. A study using microradiographic, microangiographic, and fluorescent bone-labelling techniques. Ann Rheum Dis 34:12鈥?5PubMed Central PubMed View Article
67.Bakker AC, van de Loo FA, van Beuningen HM, Sime P, van Lent PL, van der Kraan PM, Richards CD, van den Berg WB (2001) Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer dependent chondro-osteophyte formation. Osteoarthr Cartil 9:128鈥?36. doi:10.鈥?053/鈥媕oca.鈥?000.鈥?368 PubMed View Article
68.Uchino M, Izumi T, Tominaga T, Wakita R, Minehara H, Sekiguchi M, Itoman M (2000) Growth factor expression in the osteophytes of the human femoral head in osteoarthritis. Clin Orthop Relat Res 377:119鈥?25PubMed View Article
69.Mutabaruka MS, Aoulad Aissa M, Delalandre A, Lavigne M, Lajeunesse D (2010) Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression. Arthritis Res Ther 12(1):R20. doi:10.鈥?186/鈥媋r2925 PubMed Central PubMed View Article
70.Karvonen-Gutierrez CA, Harlow SD, Jacobson J, Mancuso P, Jiang Y (2014) The relationship between longitudinal serum leptin measures and measures of magnetic resonance imaging-assessed knee joint damage in a population of mid-life women. Ann Rheum Dis 73(5):883鈥?89. doi:10.鈥?136/鈥媋nnrheumdis-2012-202685 PubMed Central PubMed View Article
71.Xie H, Tang SY, Luo XH, Huang J, Cui RR, Yuan LQ, Zhou HD, Wu XP, Liao EY (2007) Insulin-like effects of visfatin on human osteoblasts. Calcif Tissue Int 80:201鈥?10. doi:10.鈥?007/鈥媠00223-006-0155-7 PubMed View Article
72.Ioan-Facsinay A, Kloppenburg M (2013) An emerging player in knee osteoarthritis: the infrapatellar fat pad. Arthritis Res Ther 15:225PubMed Central PubMed View Article
73.Distel E, Cadoudal T, Durant S, Poignard A, Chevalier X, Benelli C (2009) The infrapatellar fat pad in knee osteoarthritis: an important source of interleukin-6 and its soluble receptor. Arthritis Rheum 60:3374鈥?377. doi:10.鈥?002/鈥媋rt.鈥?4881 PubMed View Article
74.Gandhi R, Takahashi M, Virtanen C, Syed K, Davey JR, Mahomed NN (2011) Microarray analysis of the infrapatellar fat pad in knee osteoarthritis: relationship with joint inflammation. J Rheumatol 38:1966鈥?972. doi:10.鈥?899/鈥媕rheum.鈥?01302 PubMed View Article
75.Ayral X, Pickering EH, Woodworth TG, Mackillop N, Dougados M (2005) Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis鈥攔esults of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthr Cartil 13:361鈥?67. doi:10.鈥?016/鈥媕.鈥媕oca.鈥?005.鈥?1.鈥?05 PubMed View Article
76.Hao D, Li M, Wu Z, Duan Y, Li D, Qiu G (2011) Synovial fluid level of adiponectin correlated with levels of aggrecan degradation markers in osteoarthritis. Rheumatol Int 31:1433鈥?437. doi:10.鈥?007/鈥媠00296-010-1516-0 PubMed View Article
77.Honsawek S, Chayanupatkul M (2010) Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity. Arch Med Res 41:593鈥?98. doi:10.鈥?016/鈥媕.鈥媋rcmed.鈥?010.鈥?1.鈥?07 PubMed View Article
78.Staikos C, Ververidis A, Drosos G, Manolopoulos VG, Verettas DA, Tavridou A (2013) The association of adipokine levels in plasma and synovial fluid with the severity of knee osteoarthritis. Rheumatology 52(6):1077鈥?083. doi:10.鈥?093/鈥媟heumatology/鈥媖es422 PubMed View Article
79.Bas S, Finckh A, Puskas GJ, Suva D, Hoffmeyer P, Gabay C, L眉bbeke A (2014) Adipokines correlate with pain in lower limb osteoarthritis: different associations in hip and knee. Int Orthop 38:2577鈥?583. doi:10.鈥?007/鈥媠00264-014-2416-9 PubMed View Article - 作者单位：Magdalena Richter (1)
Tomasz Trzeciak (1)
Maciej Owecki (2)
Andrzej Pucher (1)
Jacek Kaczmarczyk (1)
1. Department of Orthopedics and Traumatology, Poznan University of Medical Sciences, Poznan, Poland
2. Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Orthopedics - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-5195
文摘
Osteoarthritis (OA) is one of the most common causes of musculoskeletal disability in the world. Traditionally, it has been thought that obesity contributes to the development and progression of OA by increased mechanical load of the joint structures. Nevertheless, studies have shown that adipose tissue-derived cytokines (adipocytokines) are a possible link between obesity and OA. Furthermore, according to recent findings, not only articular cartilage may be the main target of these cytokines but also the synovial membrane, subchondral bone and infrapatellar fat pad may be encompassed in the process of degradation. This review presents the most recent reports on the contribution of adipocytokines to the knee joint cartilage degradation, osteophyte formation, infrapatellar fat pad alterations and synovitis.