Genetic Background, Adipocytokines, and Metabolic Disorders in Postmenopausal Overweight and Obese Women

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• 作者：Bogna Grygiel-Górniak ; Elżbieta Kaczmarek ; Maria Mosor…
• 关键词：Postmenopausal obesity ; PPAR gamma ; 2 and beta3 ; AR polymorphism ; Adipocytokines ; Metabolic disorders ; Body fat distribution
• 刊名：Biochemical Genetics
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：54
• 期：5
• 页码：636-652
• 全文大小：406 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Human Genetics
  Biochemistry
  Zoology
  Medical Microbiology
  
• 出版者：Springer Netherlands
• ISSN：1573-4927
• 卷排序：54

文摘

The relationship between the genetic background, adipocytokines, and metabolic state in postmenopausal women has not yet been fully described. The aim of this study was to determine the relationship between PPAR gamma-2 (Pro12Ala, C1431T) and ADRB3 (Trp64Arg) polymorphisms and serum adipocytokines (adiponectin, visfatin, and resistin) and metabolic disorders in 176 postmenopausal women with increased body mass (BMI ≥ 25 kg m−2). The distributions of selected alleles and genotype frequencies were determined with the PCR–RFLP method. The bioimpedance method was used to determine nutritional status, and enzyme-linked immunosorbent assays were applied to determine serum concentrations of adipocytokines. Viscerally obese postmenopausal women had higher body mass, body fat content, serum glucose, insulin, total cholesterol, LDL, triglycerides, uric acid, and HOMA-IR and a higher prevalence of the Ala12 allele. In models based on cytokine concentration, higher body mass and glucose concentration (visfatin model, p = 0.008) and higher insulin and triglyceride levels (resistin model, p = 0.002) were observed in visceral fat deposition and this was potentiated by the presence of the T1431 allele. In resistin models, co-existence of Ala12/X polymorphisms with the T1431 allele was associated with higher resistin and triglyceride concentrations (p = 0.045). In postmenopausal women, metabolic parameters are mainly determined by the distribution of body fat, but Ala12/X polymorphism may increase the metabolic disorders and this effect can be enhanced by the T1431 allele.