Metabolomics uncovers the role of adipose tissue PDXK in adipogenesis and systemic insulin sensitivity
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- 作者：José María Moreno-Navarrete ; Mariona Jove ; Francisco Ortega ; Gemma Xifra…
- 关键词：Adipogenesis ; Insulin sensitivity ; Obesity ; PDXK ; Vitamin B6
- 刊名：Diabetologia
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：59
- 期：4
- 页码：822-832
- 全文大小：692 KB
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Mariona Jove (3)
Francisco Ortega (1) (2)
Gemma Xifra (1) (2)
Wifredo Ricart (1) (2)
Èlia Obis (3)
Reinald Pamplona (3)
Manuel Portero-Otin (3)
José Manuel Fernández-Real (1) (2)
1. Department of Diabetes, Endocrinology and Nutrition, Institut d’Investigació Biomèdica de Girona (IdIBGi), Hospital of Girona ‘Dr Josep Trueta’, Carretera de França s/n, 17007, Girona, Spain
2. Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain http://www.ciberobn.es
3. Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (IRBLleida)-PCiTAL, Lleida, Spain - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Internal Medicine
Metabolic Diseases
Human Physiology - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-0428
文摘
Aims/hypothesis We aimed to investigate the potential mechanisms involved in the compromised adipogenesis of visceral (VAT) vs subcutaneous adipose tissue (SAT) using comparative metabolomics. Based on the differentially identified metabolites, we focused on the relationship between the active form of vitamin B6 (pyridoxal 5-phosphate [PLP]), known to be generated through pyridoxal kinase (PDXK), and adipogenesis.