MITF and PU.1 inhibit adipogenesis of ovine primary preadipocytes by restraining C/EBPβ
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- 作者：ChongMei Ruan ; Xiu Li ; JunJie Hu ; Yong Zhang…
- 关键词：Adipogenesis ; Lineage ; specific transcription factor ; Microphthalmia ; associated transcription factor ; PU box ; binding protein ; CCAAT ; enhancer ; binding protein ; β
- 刊名：Cellular & Molecular Biology Letters
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：22
- 期：1
- 全文大小：3644KB
- 刊物主题：Cell Biology; Biochemistry, general; Biological and Medical Physics, Biophysics; Biotechnology; Molecular Medicine;
- 出版者：BioMed Central
- ISSN：1689-1392
- 卷排序：22
文摘
BackgroundPU box-binding protein (PU.1) is a master gene of hematopoietic lineage and an important specific transcription factor in osteoclast lineage. There is proof of its expression in adipose tissue, and it is known to significantly and negatively affect adipogenesis. However, it is unclear whether there are any other molecules involved in this process.