Immunopotentiation of four natural adjuvants co-administered with a highly pathogenic porcine reproductive and respiratory syndrome virus glycoprotein 5 subunit

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• 作者：Jun Peng ; Yanmei Yuan ; Si Shen ; Zhongxiang Niu ; Yijun Du ; Jiaqiang Wu…
• 关键词：Immunological enhancement effect ; Natural immune adjuvant ; Porcine reproductive and respiratory syndrome virus subunit
• 刊名：Virus Genes
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：52
• 期：2
• 页码：261-269
• 全文大小：917 KB
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• 作者单位：Jun Peng (1) (2)
  Yanmei Yuan (1) (2)
  Si Shen (1) (2)
  Zhongxiang Niu (1) (2)
  Yijun Du (3)
  Jiaqiang Wu (3)
  Jun Li (3)
  Jiang Yu (3)
  Tao Wang (1) (2)
  Jinbao Wang (1) (3)
  
  1. College of Veterinary Medicine, Shandong Agricultural University, Taian, China
  2. Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Taian, China
  3. Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Sangyuan Road No. 10, Jinan, 250100, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Medical Microbiology
  Virology
  Plant Sciences
  
• 出版者：Springer Netherlands
• ISSN：1572-994X

文摘

To improve the efficacy of porcine reproductive and respiratory syndrome virus (PRRSV) subunit vaccine, the immunological enhancement effects of four natural adjuvants were compared, including Astragalus extract, Astragalus/Bacillus production, propolis, and Freund’s adjuvant. The results showed that titers of IgG and neutralizing antibody against highly pathogenic PRRSV (HP-PRRSV) glycoprotein 5 (GP5) from the groups of Astragalus/Bacillus adjuvant and Freund’s adjuvant co-administered with a recombinant HP-PRRSV GP5 subunit were the highest among all the experimental groups. In cellular immunity, as shown in T lymphocyte proliferation level, Astragalus/Bacillus adjuvant and Freund’s adjuvant exhibited the most potent immunological enhancement effects. Exceptionally, pigs inoculated with Freund’s adjuvant developed severely delayed humoral immune responses within 28 days post inoculation. The adjuvants of Astragalus extract and propolis also exhibited immunological enhancement effects on humoral immune and cell-mediated immune responses, but which were obviously lower than Astragalus/Bacillus adjuvant and Freund’s adjuvant. Following challenge with HP-PRRSV, pigs inoculated with Astragalus/Bacillus adjuvant and Freund’s adjuvant co-administered with GP5 subunit showed lower viremia, slighter clinical signs, and less pathological lung lesions compared with the groups inoculated using Astragalus extract and propolis. In conclusion, from immune responses and immunological protection against HP-PRRSV, the Astragalus/Bacillus adjuvant demonstrated the most potent immunological enhancement effect on HP-PRRSV GP5 subunit. Astragalus/Bacillus adjuvant showed promise as a candidate immune adjuvant, to more efficiently prevent and control PRRS.