Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response
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- 作者：Darin K. Edwards ; Edith Jasny ; Heesik Yoon…
- 关键词：mRNA ; Vaccine ; Innate ; In vitro ; MIMIC ; Adjuvant ; Human ; Mouse ; RLRs ; CLRs ; TLRs ; Self ; adjuvantation
- 刊名：Journal of Translational Medicine
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：15
- 期：1
- 全文大小：2638KB
- 刊物主题：Biomedicine, general; Medicine/Public Health, general;
- 出版者：BioMed Central
- ISSN：1479-5876
- 卷排序：15
文摘
BackgroundProphylactic and therapeutic vaccines often depend upon a strong activation of the innate immune system to drive a potent adaptive immune response, often mediated by a strong adjuvant. For a number of adjuvants immunological readouts may not be consistent across species.