Bone Fractures with Sodium-Glucose Co-transporter-2 Inhibitors: How Real is the Risk?

详细信息    查看全文

• 作者：Edoardo Mannucci ; Matteo Monami
• 刊名：Drug Safety
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：40
• 期：2
• 页码：115-119
• 全文大小：
• 刊物主题：Drug Safety and Pharmacovigilance; Pharmacology/Toxicology;
• 出版者：Springer International Publishing
• ISSN：1179-1942
• 卷排序：40

文摘

This article succinctly summarizes the available evidence on the risk of bone fractures with sodium-glucose co-transporter-2 inhibitors. The US Food and Drug Administration has strengthened the warning for canagliflozin related to the increased risk of bone fractures, and added new information about decreased bone mineral density. The agency has also said that it will evaluate the risk of bone fractures with other drugs in the sodium-glucose co-transporter-2 inhibitor class. Increases in parathyroid hormone levels and decreases in 1,25-dihydroxyvitamin D levels have been postulated as possible mechanisms. In contrast, some studies with dapagliflozin have shown no effects on bone health. Because a consensus has not been reached, we believe that an expert opinion on how to interpret the available evidence would be of great benefit for clinicians.