Decreasing GSH and increasing ROS in chemosensitivity gliomas with IDH1 mutation

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• 作者：Jinlong Shi (1)
  Baolan Sun (1)
  Wei Shi (1)
  Hao Zuo (1)
  Daming Cui (2)
  Lanchun Ni (1)
  Jian Chen (1)
  
  1. Department of Neurosurgery ; Affiliated Hospital of Nantong University ; 20 Xisi Road ; Nantong ; Jiangsu Province ; 226001 ; People鈥檚 Republic of China
  2. Department of Neurosurgery ; Shanghai Tenth People鈥檚 Hospital ; Tongji University School of Medicine ; 301 Yanchang Road ; Shanghai ; 200072 ; China
  
• 关键词：Gliomas ; Isocitrate dehydrogenase 1 ; Glutathione ; Reactive oxygen species ; Chemotherapy
• 刊名：Tumor Biology
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：36
• 期：2
• 页码：655-662
• 全文大小：571 KB
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• 刊物主题：Cancer Research;
• 出版者：Springer Netherlands
• ISSN：1423-0380

文摘

Gliomas are the most malignant and aggressive primary brain tumor in adults. Despite concerted efforts to improve therapies, their prognosis remains very poor. Isocitrate dehydrogenase 1 (IDH1) mutations have been discovered frequently in glioma patients and are strongly correlated with improved survival. However, the effect of IDH1 mutations on the chemosensitivity of gliomas remains unclear. In this study, we generated clonal U87 and U251 glioma cell lines overexpressing the R132H mutant protein (IDH1-R132H). Compared with control cells and cells overexpressing IDH wild type (IDH1-WT), both types of IDH1-R132H cells were more sensitive to temozolomide (TMZ) and cis-diamminedichloroplatinum (CDDP) in a time- and dose-dependent manner. The IDH1-R132H-induced higher chemosensitivity was associated with nicotine adenine disphosphonucleotide (NADPH), glutathione (GSH) depletion, and reactive oxygen species (ROS) generation. Accordingly, this IDH1-R132H-induced growth inhibition was effectively abrogated by GSH in vitro and in vivo. Our study provides direct evidence that the improved survival in patients with IDH1-R132H tumors may partly result from the effects of the IDH1-R132H protein on chemosensitivity. The primary cellular events associated with improved survival are the GSH depletion and increased ROS generation.