Non-plaque-induced gingivitis associated with nicotinamide

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• 作者：Ashish Agarwal B.Sc. ; BDS ; MDS (Periodontics) ; FICDRO (1)
  
• 关键词：Drug therapy ; Gingival inflammation ; Gingivitis ; Nicotinamide ; Skin cancer
• 刊名：international journal of stomatology & occlusion medicine
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：7
• 期：4
• 页码：115-117
• 全文大小：160 KB
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• 作者单位：Ashish Agarwal B.Sc., BDS, MDS (Periodontics), FICDRO (1)
  
  1. Department of Periodontology, Institute of Dental Sciences, Pilibhit Bypass Road, 243006, Bareilly, India
  
• ISSN：1867-223X

文摘

Nicotinamide (pyridine-3-carboxamide), an amide, active form of vitamin B3, is used to treat a variety of dermatologic conditions, including skin cancer. Limited data are available regarding the adverse effects of nicotinamide in the literature. Here, we report a case of gingivitis associated with nicotinamide. A 35-year-old female patient was referred to the Department of Periodontics for the treatment of bleeding from the gums during brushing. The patient's history revealed that she had been on 12?mg/day nicotinamide for the prophylactic treatment of skin cancer for 5?months. In the absence of an obvious cause, the condition was diagnosed as nicotinamide-associated gingivitis. After consultation with the dermatologist, the drug was stopped and the patient responded favorably to periodontal treatment. Non-plaque-induced nicotinamide-associated gingivitis should always be suspected in a patient who is taking nicotinamide and has persistent gingivitis that does not respond to periodontal treatment.