Downregulated KLK13 expression in bladder cancer highlights tumor aggressiveness and unfavorable patients’ prognosis
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- 作者：Theodoros Tokas ; Margaritis Avgeris…
- 关键词：Kallikrein ; related peptidases ; Kallikrein ; related peptidase 13 ; Kallikrein 13 ; KLK ; Bladder tumors ; KLKs
- 刊名：Journal of Cancer Research and Clinical Oncology
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：143
- 期：3
- 页码：521-532
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Oncology; Cancer Research; Internal Medicine; Hematology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-1335
- 卷排序：143
文摘
PurposeDespite recent research advantages on the molecular and subcellular background, bladder cancer (BlCa) remains a clinically neglected malignancy. This is strongly reflected by the generic approach of disease diagnosis and management. Additionally, patients’ prognosis became a rather demanding task due to the great disease heterogeneity. Here, we aimed to evaluate, for the first time, the clinical value of KLK13 in BlCa.