A mild and green chemistry approach for the synthesis of symmetrical spirooxindole derivatives

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• 作者：Abbas Rahmati (1)
  Ali Hossein Rezayan (2)
  Meysam Alizadeh (1)
  Ali Nikbakht (1)
  
• 关键词：Symmetrical spirooxindole ; Isatin ; Green chemistry approach
• 刊名：Journal of the Iranian Chemical Society
• 出版年：2013
• 出版时间：June 2013
• 年：2013
• 卷：10
• 期：3
• 页码：521-525
• 全文大小：276KB
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• 作者单位：Abbas Rahmati (1)
  Ali Hossein Rezayan (2)
  Meysam Alizadeh (1)
  Ali Nikbakht (1)
  
  1. Department of Chemistry, University of Isfahan, P.O. Box 81746-73441, Isfahan, Iran
  2. Department of Life Science Engineering, Faculty of New Science and Technology, University of Tehran, Tehran, Iran
  
• ISSN：1735-2428

文摘

A simple and eco-friendly synthesis of the biologically important spirooxindole scaffold was done by the reaction of isatin with activated pyrazolones in the presence of a catalytic amount of p-toluenesulfonic acid in water at room temperature. A variety of symmetrical spirooxindole derivatives were obtained with excellent yields within short reaction time. This method is of great value because of its environmentally benign character, high yield, and easy handling.