A novel class of heterogeneous catalysts based on toluene diisocyanate: the first amine-functionalized nano-titanium dioxide as a mild and highly recyclable solid nanocatalyst for the Biginelli reaction

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• 作者：Elham Tabrizian ; Ali Amoozadeh…
• 关键词：Heterogeneous nanocatalyst ; Amine ; functionalized titania ; 2 ; 4 ; Toluene diisocyanate ; Biginelli reaction ; Experimental design
• 刊名：Reaction Kinetics, Mechanisms and Catalysis
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：119
• 期：1
• 页码：245-258
• 全文大小：938 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Catalysis
  Industrial Chemistry and Chemical Engineering
  Physical Chemistry
  
• 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
• ISSN：1878-5204
• 卷排序：119

文摘

Amine-functionalized titania as a novel inorganic–organic hybrid heterogeneous basic nanocatalyst has been synthesized by the covalent grafting of toluene diisocyanate as a precursor of amine on the surface of titania. The prepared nanocatalyst was characterized by Fourier transform infrared spectroscopy, field emission scanning electron microscopy, X-ray diffraction and thermogravimetric analysis. The catalytic activity of resultant nanocatalyst was effectively evaluated for the synthesis of 3,4-dihydopyrimidin-2(1H)-ones through a one-pot three components condensation reaction of various aldehydes, β-dicarbonyl compounds and urea (or thiourea) at 100 °C under solvent-free conditions with good to excellent yields. Optimization of the reaction condition was investigated by central composite design under response surface methodology. The catalyst can be recovered easily by simple filtration and reused for eight consecutive runs without significant decrease of its catalytic efficiency.