Metformin improves the angiogenic potential of human CD34+ cells co-incident with downregulating CXCL10 and TIMP1 gene expression and increasing VEGFA under hyperglycemia and hypoxia within a therapeutic window for myocardial infarction

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• 作者：Sherin Bakhashab ; Fahad W. Ahmed ; Hans-Juergen Schulten…
• 关键词：Hypoxia ; Hyperglycemia ; Angiogenesis ; CD34+ stem cells ; Metformin
• 刊名：Cardiovascular Diabetology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：15
• 期：1
• 全文大小：1,250 KB
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• 作者单位：Sherin Bakhashab (1) (3) (4)
  Fahad W. Ahmed (1) (2)
  Hans-Juergen Schulten (4)
  Ayat Bashir (1)
  Sajjad Karim (4)
  Abdulrahman L. Al-Malki (3)
  Mamdooh A. Gari (4)
  Adel M. Abuzenadah (4)
  Adeel G. Chaudhary (4)
  Mohammed H. Alqahtani (4)
  Sahira Lary (3)
  Farid Ahmed (4)
  Jolanta U. Weaver (1) (2)
  
  1. Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
  3. Biochemistry Department, King Abdulaziz University, Jeddah, Saudi Arabia
  4. Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia
  2. Queen Elizabeth Hospital, Gateshead, Newcastle upon Tyne, UK
  
• 刊物主题：Diabetes; Angiology; Cardiology;
• 出版者：BioMed Central
• ISSN：1475-2840

文摘

Background Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with diabetes mellitus (DM). To identify the most effective treatment for CVD, it is paramount to understand the mechanism behind cardioprotective therapies. Although metformin has been shown to reduce CVD in Type-2 DM clinical trials, the underlying mechanism remains unexplored. CD34+ cell-based therapies offer a new treatment approach to CVD. The aim of this study was to investigate the effect of metformin on the angiogenic properties of CD34+ cells under conditions mimicking acute myocardial infarction in diabetes.