Cerebellar EBV-associated diffuse large B cell lymphoma following angioimmunoblastic T cell lymphoma

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• 作者：Yi Zhou ; Marc K. Rosenblum ; Ahmet Dogan ; Achim A. Jungbluth…
• 关键词：Angioimmunoblastic T cell lymphoma ; Diffuse large B cell lymphoma ; Central nervous system
• 刊名：Journal of Hematopathology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：8
• 期：4
• 页码：235-241
• 全文大小：1,438 KB
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• 作者单位：Yi Zhou (1)
  Marc K. Rosenblum (2)
  Ahmet Dogan (2)
  Achim A. Jungbluth (2)
  April Chiu (2)
  
  1. Department of Pathology, Loyola University Medical Center, Rm 2222, Building 110, 2160 S 1st Ave, Maywood, IL, 60153, USA
  2. Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA
  
• 刊物主题：Pathology; Hematology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1865-5785

文摘

Epstein-Barr virus (EBV)-associated B cell lymphoproliferative disorders may be seen in patients with angioimmunoblastic T cell lymphoma (AITL). Although both nodal and extranodal sites of involvement have been described, central nervous system involvement by B cell lymphoma following AITL has not previously been documented. We report a first example of such unusual presentation, in which an 80-year-old man developed diffuse large B cell lymphoma (DLBCL) in the cerebellum 4 months after the initial diagnosis of AITL. EBV-encoded RNAs were detected in the DLBCL, suggesting that EBV played a pivotal role in the pathogenesis of high-grade histologic progression of AITL. The patient survived less than 9 months after his initial diagnosis of AITL. We believe that this case expands the spectrum of extranodal manifestation of EBV-positive B cell lymphoma associated with AITL and illustrates the importance of recognition of this association when encountering unusual central nervous system lesions in patients with known AITL. Keywords Angioimmunoblastic T cell lymphoma Diffuse large B cell lymphoma Central nervous system