Systemic thrombolysis in anterior spinal artery syndrome: what has to be considered?

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• 作者：Mia Koch ; Dominik Sepp ; Sascha Prothmann…
• 关键词：Anterior spinal artery syndrome ; Thrombolysis ; Magnetic resonance imaging (MRI)
• 刊名：Journal of Thrombosis and Thrombolysis
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：41
• 期：3
• 页码：511-513
• 全文大小：479 KB
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• 作者单位：Mia Koch (1)
  Dominik Sepp (1)
  Sascha Prothmann (2)
  Holger Poppert (1)
  Christian L. Seifert (1)
  
  1. Klinikum rechts der Isar, Neurologische Klinik und Poliklinik, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany
  2. Abteilung für Neuroradiologie, Institut für Röntgendiagnostik, Technische Universität München, Munich, Germany
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Cardiology
  Hematology
  
• 出版者：Springer Netherlands
• ISSN：1573-742X

文摘

Anterior spinal artery syndrome (ASAS) often leads to complete motor paralysis with poor clinical outcome. There is a lack of controlled clinical trials on acute treatment strategies in ASAS. However, systemic thrombolysis with recombinant tissue-plasminogen activator (rt-PA) might be a useful therapeutic option in ASAS. We report the management of a patient with ASAS below thoracic level 10, who was treated with intravenous thrombolysis. An 81 year old patient presented with flaccid paraplegia. After exclusion of aortal dissection, spinal tumour or haemorrhage, the patient was treated with intravenous rt-PA 3 h 40 min after symptom onset. The follow up magnetic resonance imaging (MRI) showed spinal infarction below thoracic segment 10. In the clinical course, the patient partially recovered lower limb muscle strength and was able to walk with assistance. To the best of our knowledge, this is the first case in the literature of ASAS with MRI-proven spinal ischemia and the application of rt-PA. Systemic thrombolysis seems to be justifiable in patients with ASAS after the rule-out of aortal dissection and spinal bleeding.