16-Channel Surface Coil for 13C-Hyperpolarized Spectroscopic Imaging of Cardiac Metabolism in Pig Heart

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• 作者：Francesca Frijia ; Maria Filomena Santarelli…
• 关键词：Hyperpolarized 13C ; Magnetic resonance imaging ; Pig model ; Heart metabolism ; Radio ; frequency (RF) coils ; Dynamic nuclear polarization (DNP) ; 13C pyruvate
• 刊名：Journal of Medical and Biological Engineering
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：36
• 期：1
• 页码：53-61
• 全文大小：2,521 KB
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• 作者单位：Francesca Frijia (1)
  Maria Filomena Santarelli (1) (2)
  Ulrich Koellisch (3)
  Giulio Giovannetti (1) (2)
  Titus Lanz (4)
  Alessandra Flori (1)
  Markus Durst (3)
  Giovanni Donato Aquaro (1)
  Rolf F. Schulte (5)
  Daniele De Marchi (1)
  Vincenzo Lionetti (6)
  Jan H. Ardenkjaer-Larsen (7) (8)
  Luigi Landini (1) (9)
  Luca Menichetti (1) (2)
  Vincenzo Positano (1)
  
  1. Fondazione CNR Regione Toscana “G. Monasterio”, Via Moruzzi, 1, 56124, Pisa, Italy
  2. Institute of Clinical Physiology, National Research Council, 56124, Pisa, Italy
  3. Technische Universität München, Institute of Medical Engineering, 80333, Munich, Germany
  4. Rapid Biomedical GmbH, 97222, Rimpar, Germany
  5. GE Global Research, 80333, Munich, Germany
  6. Laboratory of Medical Science, Institute of Life Sciences, Scuola Superiore Sant’Anna, 56126, Pisa, Italy
  7. Department of Electrical Engineering, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark
  8. GE Healthcare, 2605, Broendby, Denmark
  9. Department of Information Engineering, University of Pisa, 56126, Pisa, Italy
  
• 刊物类别：Biomedical Engineering; Cell Biology; Imaging / Radiology;
• 刊物主题：Biomedical Engineering; Cell Biology; Imaging / Radiology;
• 出版者：Springer Berlin Heidelberg
• ISSN：2199-4757

文摘

Magnetic resonance spectroscopy (MRS) of hyperpolarized 13C pyruvate and its metabolites in large animal models is a powerful tool for assessing cardiac metabolism in patho-physiological conditions. In 13C studies, a high signal-to-noise ratio (SNR) is crucial to overcome the intrinsic data quality limitation due to the low molar concentration of certain metabolites as well as the low flux of conversion. Since 13C-MRS is essentially a semi-quantitative technique, the SNR of the spectra acquired in different myocardial segments should be homogeneous. MRS coil design plays an important role in achieving both targets. In this study, a 16-channel receive surface coil was designed for 13C hyperpolarized studies of the pig heart with a clinical 3-T scanner. The coil performance was characterized by phantom experiments and compared with that of a birdcage coil used in transmit/receive mode. Segmental signal distribution in the left ventricle (LV) was assessed by experiments on six healthy mini pigs. The proposed coil showed a significant increase in SNR for the LV wall close to the coil surface with respect to that for the birdcage but also significant segmental inhomogeneity. Hence, the use of the 16-channel coil is recommended for studies of septal and anterior LV walls.