Apoptosis-induced lymphopenia in sepsis and other severe injuries

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• 作者：Thibaut Girardot ; Thomas Rimmelé ; Fabienne Venet ; Guillaume Monneret
• 关键词：Apoptosis ; Lymphocytes ; Injury ; Sepsis ; Burns ; Surgery ; Trauma
• 刊名：Apoptosis
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：22
• 期：2
• 页码：295-305
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Cancer Research; Cell Biology; Oncology; Biochemistry, general; Virology;
• 出版者：Springer US
• ISSN：1573-675X
• 卷排序：22

文摘

Sepsis and other acute injuries such as severe trauma, extensive burns, or major surgeries, are usually followed by a period of marked immunosuppression. In particular, while lymphocytes play a pivotal role in immune response, their functions and numbers are profoundly altered after severe injuries. Apoptosis plays a central role in this process by affecting immune response at various levels. Indeed, apoptosis-induced lymphopenia duration and depth have been associated with higher risk of infection and mortality in various clinical settings. Therapies modulating apoptosis represent an interesting approach to restore immune competence after acute injury, although their use in clinical practice still presents several limitations. After briefly describing the apoptosis process in physiology and during severe injuries, we will explore the immunological consequences of injury-induced lymphocyte apoptosis, and describe associations with clinically relevant outcomes in patients. Therapeutic perspectives targeting apoptosis will also be discussed.