Anamnestic risk factor questionnaire as reliable diagnostic instrument for osteoporosis (reduced bone morphogenic density)

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• 作者：Leila Kolios (1)
  Caner Takur (2)
  Arash Moghaddam (2)
  Mirjam Hitzler (2)
  Heinrich Schmidt-Gayk (3)
  Arnold J Suda (2)
  Bernd H?ner (4)
  Paul A Grützner (2)
  Christoph W?lfl (2)
  
• 刊名：BMC Musculoskeletal Disorders
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：12
• 期：1
• 全文大小：223KB
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  53. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2474/12/187/prepub
  
• 作者单位：Leila Kolios (1)
  Caner Takur (2)
  Arash Moghaddam (2)
  Mirjam Hitzler (2)
  Heinrich Schmidt-Gayk (3)
  Arnold J Suda (2)
  Bernd H?ner (4)
  Paul A Grützner (2)
  Christoph W?lfl (2)
  
  1. Department for Plastic-, Reconstructive and Handsurgery, Burn Care Centre, BG Unfallklinik Ludwigshafen, Ludwig-Guttmann-Str.13, 67071, Ludwigshafen, Germany
  2. Department of Trauma and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str.13, 67071, Ludwigshafen, Germany
  3. Clinical Laboratory Limbach, Im Breitspiel 15, 69126, Heidelberg, Germany
  4. Department of Social and Legal Sciences, SRH Hochschule Heidelberg, Ludwig-Guttmann-Str.6, 69123, Heidelberg, Germany
  

文摘

Background Osteoporosis is a major health problem worldwide, and is included in the WHO list of the top 10 major diseases. However, it is often undiagnosed until the first fracture occurs, due to inadequate patient education and lack of insurance coverage for screening tests. Anamnestic risk factors like positive family anamnesis or early menopause are assumed to correlate with reduced BMD. Methods In our study of 78 patients with metaphyseal long bone fractures, we searched for a correlation between anamnestic risk factors, bone specific laboratory values, and the bone morphogenic density (BMD). Each indicator was examined as a possible diagnostic instrument for osteoporosis. The secondary aim of this study was to demonstrate the high prevalence of osteoporosis in patients with metaphyseal fractures. Results 76.9% of our fracture patients had decreased bone density and 43.6% showed manifest osteoporosis in DXA (densitometry) measurements. Our questionnaire, identifying anamnestic risk factors, correlated highly significantly (p = 0.01) with reduced BMD, whereas seven bone-specific laboratory values (p = 0.046) correlated significantly. Conclusions Anamnestic risk factors correlate with pathological BMD. The medical questionnaire used in this study would therefore function as a cost-effective primary diagnostic instrument for identification of osteoporosis patients.