Synthesis of heterocycles on the basis of arylation products of unsaturated compounds. 19.* Arylation of 2-acetylthio- phene and the synthesis of 2-(5-aryl-2-thien- yl)-4-quinolinecarboxylic acids
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- 作者：V. S. Matiychuk ; N. D. Obushak ; R. Z. Lytvyn and Yu. I. Horak
- 关键词：2 ; acetyl ; 5 ; arylthiophenes ; 2 ; acetylthiophene ; 4 ; quinolinecarboxylic acid derivatives ; arylation ; Meerwein reaction ; Pfitzinger reaction
- 刊名：Chemistry of Heterocyclic Compounds
- 出版年：2010
- 出版时间：May, 2010
- 年：2010
- 卷：46
- 期：1
- 页码：50-55
- 全文大小：313.3 KB
文摘
The reaction of 2-acetylthiophene with acetylthiophene with arenediazonium chlorides in the presence of cupric chloride as catalyst gives 2-acetyl-5-arylthiophenes. These products react with 5-chloro- and 5-bromoisatins to give 6-chloro- and 6-bromo-substituted 2-(5-aryl-2-thienyl)-4-quinolinecarboxylic acids.