Antidepressant-like activity of the neuropeptide Y Y5 receptor antagonist Lu AA33810: behavioral, molecular, and immunohistochemical evidence
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- 作者：Helena Domin ; Bernadeta Szewczyk ; Bartłomiej Pochwat ; Monika Woźniak…
- 关键词：Astrocyte ; Antidepressant ; BDNF ; Lu AA33810 ; GFAP ; Neuropeptide Y ; Prefrontal cortex ; Gliotoxin ; Forced swim test
- 刊名：Psychopharmacology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：234
- 期：4
- 页码：631-645
- 全文大小：2419KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Neurosciences; Pharmacology/Toxicology; Psychiatry;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-2072
- 卷排序：234
文摘
RationaleIt has recently been found that chronic treatment with the highly selective, brain-penetrating Y5 receptor antagonist, Lu AA33810 [N-[[trans-4-[(4,5-dihydro [1] benzothiepino[5,4-d] thiazol-2-yl) amino] cyclohexyl]methyl]-methanesulfonamide], produces antidepressant-like effects in the rat chronic mild stress model.