Variation in the ribosome interacting loop of the Sec61α from Giardia lamblia

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• 作者：Abhishek Sinha ; Atrayee Ray ; Sandipan Ganguly ; Shubhra Ghosh Dastidar…
• 关键词：Giardia ; Sec61 ; Homology modeling ; Ribosome ; Endoplasmic reticulum ; Molecular dynamics
• 刊名：Biology Direct
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：10
• 期：1
• 全文大小：2,158 KB
• 刊物主题：Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1745-6150

文摘

The interaction between the ribosome and the endoplasmic reticulum-located Sec61 protein translocon is mediated through an arginine residue of Sec61α, which is conserved in all prokaryotic and eukaryotic orthologues characterized to date. Using in silico approaches we report that instead of arginine, this ribosome-interaction function is most likely discharged by a lysine residue in the protist Giardia lamblia. This functional substitution of the R with a K in GlSec61α may have taken place to accommodate a G-rich rRNA.