The Association of Genetic Predisposition to Depressive Symptoms with Non-suicidal and Suicidal Self-Injuries

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• 作者：Dominique F. Maciejewski ; Miguel E. Renteria ; Abdel Abdellaoui…
• 关键词：Depression ; Suicidal ideation ; Suicide attempts ; Self ; injury ; Polygenic risk ; Genetics
• 刊名：Behavior Genetics
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：47
• 期：1
• 页码：3-10
• 全文大小：424KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Clinical Psychology; Health Psychology; Public Health;
• 出版者：Springer US
• ISSN：1573-3297
• 卷排序：47

文摘

Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressive symptoms with lifetime NSSI, suicidal ideation, and suicide attempts in a sample of 6237 Australian adult twins and their family members (3740 females, mean age = 42.4 years). Polygenic risk scores for depressive symptoms significantly predicted suicidal ideation, and some predictive ability was found for suicide attempts; the polygenic risk scores explained a significant amount of variance in suicidal ideation (lowest p = 0.008, explained variance ranging from 0.10 to 0.16 %) and, less consistently, in suicide attempts (lowest p = 0.04, explained variance ranging from 0.12 to 0.23 %). Polygenic risk scores did not significantly predict NSSI. Results highlight that individuals genetically predisposed to depression are also more likely to experience suicidal ideation/behaviour, whereas we found no evidence that this is also the case for NSSI.