Phosphorylation-dependent regulation of ALDH1A1 by Aurora kinase A: insights on their synergistic relationship in pancreatic cancer
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- 作者：Jing Wang ; Kumar Nikhil ; Keith Viccaro ; Lei Chang ; Jacoba White ; Kavita Shah
- 关键词：Aurora kinase A ; ALDH1A1 ; Chemical genetic ; Epithelial ; to ; mesenchymal transition ; Therapy
- 刊名：BMC Biology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：15
- 期：1
- 全文大小：7893KB
- 刊物主题：Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1741-7007
- 卷排序：15
文摘
BackgroundEpithelial-to-mesenchymal transition (EMT) and cancer stem cell (CSC) formation are key underlying causes that promote extensive metastasis, drug resistance, and tumor recurrence in highly lethal pancreatic cancer. The mechanisms leading to EMT and CSC phenotypes are not fully understood, which has hindered the development of effective targeted therapies capable of improving treatment outcomes in patients with pancreatic cancer.