BRAF V600E-dependent role of autophagy in uveal melanoma

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• 作者：Yinu Zhao ; Weibin Wang ; Irene Min…
• 关键词：Uveal melanoma ; Autophagy ; BRAF mutation ; BRAF inhibitor
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：143
• 期：3
• 页码：447-455
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Oncology; Cancer Research; Internal Medicine; Hematology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1335
• 卷排序：143

文摘

BackgroundAutophagy can function in a dual role in cancer development and progression: It can be cytoprotective or contribute to cell death. Therefore, determining the contextual role of autophagy between these two opposing effects is important. So far, little is known about the role of autophagy in uveal melanoma. In the present study, we looked to investigate the autophagic process, as well as its effect on cell survival in uveal melanoma cell lines under stressed conditions (starvation). The possible role of autophagy during BRAF inhibition in uveal melanoma was also sought.