Sperm dysfunction and ciliopathy

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• 作者：Kazuo Inaba ; Katsutoshi Mizuno
• 关键词：Cilia ; Ciliopathy ; Dynein ; Flagella ; Sperm ; Infertility
• 刊名：Reproductive Medicine and Biology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：15
• 期：2
• 页码：77-94
• 全文大小：1,306 KB
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• 作者单位：Kazuo Inaba (1)
  Katsutoshi Mizuno (1) (2)
  
  1. Shimoda Marine Research Center, University of Tsukuba, 5-10-1 Shimoda, Shizuoka, 415-0025, Japan
  2. Department of Biological Sciences, Dartmouth College, Hanover, NH, 03755, USA
  
• 刊物主题：Reproductive Medicine; Gynecology; Urology/Andrology;
• 出版者：Springer Japan
• ISSN：1447-0578

文摘

Sperm motility is driven by motile cytoskeletal elements in the tail, called axonemes. The structure of axonemes consists of 9 + 2 microtubules, molecular motors (dyneins), and their regulatory structures. Axonemes are well conserved in motile cilia and flagella through eukaryotic evolution. Deficiency in the axonemal structure causes defects in sperm motility, and often leads to male infertility. It has been known since the 1970s that, in some cases, male infertility is linked with other symptoms or diseases such as Kartagener syndrome. Given that these links are mostly caused by deficiencies in the common components of cilia and flagella, they are called “immotile cilia syndrome” or “primary ciliary dyskinesia,” or more recently, “ciliopathy,” which includes deficiencies in primary and sensory cilia. Here, we review the structure of the sperm flagellum and epithelial cilia in the human body, and discuss how male fertility is linked to ciliopathy.