Improvement of memory and learning by intracerebroventricular microinjection of T3 in rat model of ischemic brain stroke mediated by upregulation of BDNF and GDNF in CA1 hippocampal region

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• 作者：Tahmineh Mokhtari ; Mohammad Akbari…
• 关键词：Triiodothyronine ; BDNF ; GDNF ; CA1 ; Stroke
• 刊名：DARU Journal of Pharmaceutical Sciences
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：25
• 期：1
• 全文大小：1001KB
• 刊物主题：Pharmaceutical Sciences/Technology; Pharmacology/Toxicology; Medicinal Chemistry;
• 出版者：BioMed Central
• ISSN：2008-2231
• 卷排序：25

文摘

BackgroundIschemic stroke is a common leading cause of death and disability with lack of effective therapies. In this study, T3 was intra-ventricularly injected to evaluate gene expression and protein concentration of and brain-derived neurotrophic factor (BDNF) and Glial cell-derived neurotrophic factor (GDNF) in hippocampal CA1 region in rat model of brain ischemia/reperfusion (I/R).