Microwave-assisted synthesis and evaluation of indole based benzofuran scaffolds as antimicrobial and antioxidant agents
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- 作者：D. Ashok ; G. Srinivas ; A. V. Kumar ; D. M. Gandhi
- 关键词：indole ; benzofuran ; Claisen–Schmidt reaction ; microwave irradiation ; antimicrobial activity ; antioxidant activity
- 刊名：Russian Journal of Bioorganic Chemistry
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：42
- 期：5
- 页码：560-566
- 全文大小：216 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Biochemistry
Bioorganic Chemistry
Organic Chemistry
Biomedicine
Russian Library of Science - 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
- ISSN：1608-330X
- 卷排序：42
文摘
A novel series of indole based benzofuran derivatives has been synthesized under microwave irradiation and conventional conditions. The structures of the compounds were established on the basis of 1HNMR, 13C NMR, IR and mass spectral data. The analogues were evaluated for their in vitro antimicrobial activity against two gram-positive bacteria, two gram-negative bacteria and two fungal strains. The same series was screened for in vitro antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH). Most of the title compounds exhibited promising antimicrobial and antioxidant activities.