Replication of CNTNAP2 association with nonword repetition and support for FOXP2 association with timed reading and motor activities in a dyslexia family sample

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• 作者：Beate Peter (1) (2)
  Wendy H. Raskind (2) (5)
  Mark Matsushita (2)
  Mark Lisowski (2)
  Tiffany Vu (2)
  Virginia W. Berninger (3)
  Ellen M. Wijsman (2) (4)
  Zoran Brkanac (5)
  
• 关键词：Written language ; Spoken language ; Modality ; specific motor sequencing ; Quantitative transmission disequilibrium ; Linear modeling
• 刊名：Journal of Neurodevelopmental Disorders
• 出版年：2011
• 出版时间：March 2011
• 年：2011
• 卷：3
• 期：1
• 页码：39-49
• 全文大小：234KB
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• 作者单位：Beate Peter (1) (2)
  Wendy H. Raskind (2) (5)
  Mark Matsushita (2)
  Mark Lisowski (2)
  Tiffany Vu (2)
  Virginia W. Berninger (3)
  Ellen M. Wijsman (2) (4)
  Zoran Brkanac (5)
  
  1. Department of Speech and Hearing Sciences, University of Washington, P.O. Box聽354875, Seattle, WA, 98195, USA
  2. Department of Medicine, University of Washington, P.O. Box聽354875, Seattle, WA, 98195, USA
  5. Department of Psychiatry and Behavioral Sciences, University of Washington, P.O. Box聽354875, Seattle, WA, 98195, USA
  3. Department of Educational Psychology, University of Washington, P.O. Box聽354875, Seattle, WA, 98195, USA
  4. Department of Biostatistics, University of Washington, P.O. Box聽354875, Seattle, WA, 98195, USA
  

文摘

Two functionally related genes, FOXP2 and CNTNAP2, influence language abilities in families with rare syndromic and common nonsyndromic forms of impaired language, respectively. We investigated whether these genes are associated with component phenotypes of dyslexia and measures of sequential motor ability. Quantitative transmission disequilibrium testing (QTDT) and linear association modeling were used to evaluate associations with measures of phonological memory (nonword repetition, NWR), expressive language (sentence repetition), reading (real word reading efficiency, RWRE; word attack, WATT), and timed sequential motor activities (rapid alternating place of articulation, RAPA; finger succession in the dominant hand, FS-D) in 188 family trios with a child with dyslexia. Consistent with a prior study of language impairment, QTDT in dyslexia showed evidence of CNTNAP2 single nucleotide polymorphism (SNP) association with NWR. For FOXP2, we provide the first evidence for SNP association with component phenotypes of dyslexia, specifically NWR and RWRE but not WATT. In addition, FOXP2 SNP associations with both RAPA and FS-D were observed. Our results confirm the role of CNTNAP2 in NWR in a dyslexia sample and motivate new questions about the effects of FOXP2 in neurodevelopmental disorders.