The SLC34 family of sodium-dependent phosphate transporters

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• 作者：Carsten A. Wagner (1)
  Nati Hernando (1)
  Ian C. Forster (1)
  Jürg Biber (1)
  
• 关键词：SLC34 family ; Sodium ; dependent phosphate transporters ; Phosphate ; SLC34A1 ; SLC34A2 ; SLC34A3
• 刊名：Pfl篓鹿gers Archiv - European Journal of Physiology
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：466
• 期：1
• 页码：139-153
• 全文大小：739 KB
• 作者单位：Carsten A. Wagner (1)
  Nati Hernando (1)
  Ian C. Forster (1)
  Jürg Biber (1)
  
  1. Institute of Physiology, University of Zurich, Winterthurerstrasse, Zurich, 190 8057, Switzerland
  
• ISSN：1432-2013

文摘

The SLC34 family of sodium-driven phosphate cotransporters comprises three members: NaPi-IIa (SLC34A1), NaPi-IIb (SLC34A2), and NaPi-IIc (SLC34A3). These transporters mediate the translocation of divalent inorganic phosphate (HPO4 2?/sup>) together with two (NaPi-IIc) or three sodium ions (NaPi-IIa and NaPi-IIb), respectively. Consequently, phosphate transport by NaPi-IIa and NaPi-IIb is electrogenic. NaPi-IIa and NaPi-IIc are predominantly expressed in the brush border membrane of the proximal tubule, whereas NaPi-IIb is found in many more organs including the small intestine, lung, liver, and testis. The abundance and activity of these transporters are mostly regulated by changes in their expression at the cell surface and are determined by interactions with proteins involved in scaffolding, trafficking, or intracellular signaling. All three transporters are highly regulated by factors including dietary phosphate status, hormones like parathyroid hormone, 1,25-OH2 vitamin D3 or FGF23, electrolyte, and acid–base status. The physiological relevance of the three members of the SLC34 family is underlined by rare Mendelian disorders causing phosphaturia, hypophosphatemia, or ectopic organ calcifications.