A Perspective on the Clinical Translation of Scaffolds for Tissue Engineering

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• 作者：Matthew J. Webber (1)
  Omar F. Khan (1)
  Stefanie A. Sydlik (1)
  Benjamin C. Tang (1)
  Robert Langer (1) (2) (3) (4)
  
  1. Koch Institute for Integrative Cancer Research ; Massachusetts Institute of Technology ; 77 Massachusetts Avenue ; Room 76-661 ; Cambridge ; MA ; 02139 ; USA
  2. Department of Chemical Engineering ; Massachusetts Institute of Technology ; Cambridge ; MA ; 02139 ; USA
  3. Institute for Medical Engineering and Science ; Massachusetts Institute of Technology ; Cambridge ; MA ; 02139 ; USA
  4. Harvard-MIT Division of Health Sciences and Technology ; Massachusetts Institute of Technology ; Cambridge ; MA ; 02139 ; USA
  
• 关键词：Stem cells ; Scaffolds ; Engineering constraints ; FDA approval ; Entrepreneurial biotechnology ; Material properties
• 刊名：Annals of Biomedical Engineering
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：43
• 期：3
• 页码：641-656
• 全文大小：406 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  Biomedical Engineering
  Biophysics and Biomedical Physics
  Mechanics
  Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-9686

文摘

Scaffolds have been broadly applied within tissue engineering and regenerative medicine to regenerate, replace, or augment diseased or damaged tissue. For a scaffold to perform optimally, several design considerations must be addressed, with an eye toward the eventual form, function, and tissue site. The chemical and mechanical properties of the scaffold must be tuned to optimize the interaction with cells and surrounding tissues. For complex tissue engineering, mass transport limitations, vascularization, and host tissue integration are important considerations. As the tissue architecture to be replaced becomes more complex and hierarchical, scaffold design must also match this complexity to recapitulate a functioning tissue. We outline these design constraints and highlight creative and emerging strategies to overcome limitations and modulate scaffold properties for optimal regeneration. We also highlight some of the most advanced strategies that have seen clinical application and discuss the hurdles that must be overcome for clinical use and commercialization of tissue engineering technologies. Finally, we provide a perspective on the future of scaffolds as a functional contributor to advancing tissue engineering and regenerative medicine.