Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding

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• 作者：Linn Gillberg ; Alexander Perfilyev ; Charlotte Brøns ; Martin Thomasen…
• 关键词：Diet ; Epigenetics ; Gene expression ; High ; fat overfeeding ; Low birthweight ; Metabolism ; Obesity ; Type 2 diabetes
• 刊名：Diabetologia
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：59
• 期：4
• 页码：799-812
• 全文大小：642 KB
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• 作者单位：Linn Gillberg (1) (2)
  Alexander Perfilyev (3)
  Charlotte Brøns (1)
  Martin Thomasen (1)
  Louise G. Grunnet (1)
  Petr Volkov (3)
  Fredrik Rosqvist (4)
  David Iggman (4) (5)
  Ingrid Dahlman (6)
  Ulf Risérus (4)
  Tina Rönn (3)
  Emma Nilsson (1) (3)
  Allan Vaag (1) (2)
  Charlotte Ling (3)
  
  1. Department of Endocrinology, Rigshospitalet, Section 7652, Tagensvej 20, DK-2200, Copenhagen N, Denmark
  2. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  3. Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University, Jan Waldenströms gata 35, SE-20502, Malmö, Sweden
  4. Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
  5. Center for Clinical Research Dalarna, Falun, Sweden
  6. Department of Medicine, Karolinska Institutet, Huddinge, Stockholm, Sweden
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

Aims/hypothesis Individuals who had a low birthweight (LBW) are at an increased risk of insulin resistance and type 2 diabetes when exposed to high-fat overfeeding (HFO). We studied genome-wide mRNA expression and DNA methylation in subcutaneous adipose tissue (SAT) after 5 days of HFO and after a control diet in 40 young men, of whom 16 had LBW.