Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight

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• 作者：Kris Genelyn Dimasuay ; Elizabeth H. Aitken ; Fredrick Rosario ; Madi Njie…
• 关键词：Intervillositis ; Fetal growth restriction ; System A transporter ; Deptor
• 刊名：BMC Medicine
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：15
• 期：1
• 全文大小：1586KB
• 刊物主题：Medicine/Public Health, general; Biomedicine, general;
• 出版者：BioMed Central
• ISSN：1741-7015
• 卷排序：15

文摘

BackgroundPlacental Plasmodium falciparum malaria can trigger intervillositis, a local inflammatory response more strongly associated with low birthweight than placental malaria infection alone. Fetal growth (and therefore birthweight) is dependent on placental amino acid transport, which is impaired in placental malaria-associated intervillositis. Here, we tested the hypothesis that mechanistic target of rapamycin (mTOR) signaling, a pathway known to regulate amino acid transport, is inhibited in placental malaria-associated intervillositis, contributing to lower birthweight.