Anthocyanins and phenolic acids from a wild blueberry (Vaccinium angustifolium) powder counteract lipid accumulation in THP-1-derived macrophages

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• 作者：Cristian Del Bo’ ; Yi Cao ; Martin Roursgaard ; Patrizia Riso…
• 关键词：Wild blueberry ; Polyphenols ; THP ; 1 macrophages ; Lipid accumulation
• 刊名：European Journal of Nutrition
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：55
• 期：1
• 页码：171-182
• 全文大小：1,006 KB
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• 作者单位：Cristian Del Bo’ (1)
  Yi Cao (2)
  Martin Roursgaard (2)
  Patrizia Riso (1)
  Marisa Porrini (1)
  Steffen Loft (2)
  Peter Møller (2)
  
  1. Department of Food, Environmental and Nutritional Sciences–Division of Human Nutrition, Università degli Studi di Milano, Milan, Italy
  2. Department of Public Health, University of Copenhagen, Copenhagen, Denmark
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nutrition
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1436-6215

文摘

Purpose Blueberries are a rich source of anthocyanins (ACNs) and phenolic acids (PA), which are hypothesized to protect against development of atherosclerosis. The present study examined the effect of an ACN- and PA-rich fractions, obtained from a wild blueberry powder, on the capacity to counteract lipid accumulation in macrophages derived from monocytic THP-1 cells. In addition, we tested the capacity of pure ACNs and their metabolites to alter lipid accumulation.