Interaction of Curcumin with Manganese May Compromise Metal and Neurotransmitter Homeostasis in the Hippocampus of Young Mice
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- 作者：Ariana Ern Schmitz (1)
Paulo Alexandre de Oliveira (2)
Luiz F. de Souza (1)
Danilo Grünig Humberto da Silva (3)
Samara Danielski (1)
Danúbia Bonfanti Santos (1)
Eduardo Alves de Almeida (3)
Rui Daniel Prediger (2)
Andrew Fisher (4)
Marcelo Farina (1)
Alcir Luiz Dafre (1) - 关键词：Manganese ; Curcumin ; Idiopathic Parkinson disease ; Memory ; Motor performance
- 刊名：Biological Trace Element Research
- 出版年：2014
- 出版时间：June 2014
- 年：2014
- 卷：158
- 期：3
- 页码：399-409
- 全文大小：
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Paulo Alexandre de Oliveira (2)
Luiz F. de Souza (1)
Danilo Grünig Humberto da Silva (3)
Samara Danielski (1)
Danúbia Bonfanti Santos (1)
Eduardo Alves de Almeida (3)
Rui Daniel Prediger (2)
Andrew Fisher (4)
Marcelo Farina (1)
Alcir Luiz Dafre (1)
1. Department of Biochemistry, Federal University of Santa Catarina, Biological Sciences Centre, 88040-900, Florianópolis, SC, Brazil
2. Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, SC, Brazil
3. Department of Chemistry and Environmental Sciences, University Paulista Júlio de Mesquita Filho, S?o Paulo, SP, Brazil
4. School of Geography, Earth and Environmental Sciences, University of Plymouth, PL4 8AA, Plymouth, UK - ISSN：1559-0720
文摘
Manganese (Mn) exposure is related to industrial activities, where absorption by inhalation has high relevance. Manganism, a syndrome caused as a result of excessive accumulation of Mn in the central nervous system, has numerous symptoms similar to those seen in idiopathic Parkinson disease (IPD). Some of these symptoms, such as learning, memory, sensorial, and neurochemical changes, appear before the onset of motor deficits in both manganism and IPD. The aim of this study was to evaluate the possible neuroprotective effects of curcumin against behavioral deficits induced by Mn toxicity in young (2?months old) Swiss mice. We evaluated the effect of chronic inhalation of a Mn mixture [Mn(OAc)3 and MnCl2 (20:40?mM)], 1?h/session, three times a week, over a 14-week period on behavioral and neurochemical parameters. Curcumin was supplemented in the diet (500 or 1,500?ppm in food pellets). The Mn disrupted the motor performance evaluated in the single-pellet reach task, as well as the short- and long-term spatial memory evaluated in the step-down inhibitory avoidance task. Surprisingly, curcumin also produced similar deleterious effects in such behavioral tests. Moreover, the association of Mn plus curcumin significantly increased the levels of Mn and iron, and decreased the levels of dopamine and serotonin in the hippocampus. These alterations were not observed in the striatum. In conclusion, the current Mn treatment protocol resulted in mild deficits in motor and memory functions, resembling the early phases of IPD. Additionally, curcumin showed no beneficial effects against Mn-induced disruption of hippocampal metal and neurotransmitter homeostasis. Figure ?/div>