Antimicrobic features of phenolic lipids

详细信息    查看全文

• 作者：Yu. A. Nikolaev ; I. A. Borzenkov ; M. V. Kalinin ; N. G. Loiko ; A. L. Tarasov ; V. K. Plakunov ; S. S. Belyaev ; N. V. Voronina ; V. F. Gal¡¯chenko and G. I. El?Registan
• 刊名：Applied Biochemistry and Microbiology
• 出版年：2010
• 出版时间：March, 2010
• 年：2010
• 卷：46
• 期：2
• 页码：159-165
• 全文大小：155.7 KB

文摘

The connection between the efficiency of phenolic lipids and their hydrophobic property (solubility) and hydrophobic property of microorganisms’ cell structure is shown. The mixture of amphiphilic di(oxiphenil)-phenil-methanes, which act bacteriostatically under 15 mg/l, possesses maximal efficiency against Staphylococcus aureus. Against Mycobacterium smegmatis with hydrophobic cell wall, hydrophobic 2,4-dialkylocibenzol 70 mg/l was the most effective. Hexylresorcin (HR) stops the development of gram-positive bacteria in concentrations 20–50 mg/l, that of gram-negative bacteria in concentration 65 mg/l, that of M. smegmatis at 70 mg/l, and that of yeast and fungi at 300 mg/l. HR prevails bacteria spores germination in the concentration 25–100 mg/l. The dependence of antibacterial action of isomers and homologues of alkylresorcins on their structure-number, position, and length of alkyl substituents-is studied.