The WE-Study: does botulinum toxin A make walking easier in children with cerebral palsy?: Study protocol for a randomized controlled trial
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- 作者：Siri Merete Brændvik ; Karin Roeleveld ; Guro Lillemoen Andersen…
- 关键词：Cerebral palsy ; Spasticity ; Botulinum toxin A ; Walking ; Energy cost ; Activity ; Pain
- 刊名：Trials
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：480KB
- 刊物主题：Medicine/Public Health, general; Biomedicine, general; Statistics for Life Sciences, Medicine, Health Sciences;
- 出版者：BioMed Central
- ISSN：1745-6215
- 卷排序：18
文摘
BackgroundIntramuscular injections of botulinum toxin A (BoNT-A) have been a cornerstone in the treatment of spasticity for the last 20 years. In Norway, the treatment is now offered to two out of three children with spastic cerebral palsy (CP). However, despite its common use, the evidence for its functional effects is limited and inconclusive. The objective of this study is to determine whether BoNT-A makes walking easier in children with CP. We hypothesize that injections with BoNT-A in the calf muscles will reduce energy cost during walking, improve walking capacity, increase habitual physical activity, reduce pain and improve self-perceived performance and satisfaction.