Mathematical modeling of the first phase of morphogenesis of mechanoreceptors in D. melanogaster

详细信息    查看全文

• 作者：T. A. Bukharina (1) bukharina@bionet.nsc.ru
  V. P. Golubyatnikov (23) glbtn@math.nsc.ru
  I. V. Golubyatnikov (2) ivan.golubyatnikov@gmail.com
  D. P. Furman (13) furman@bionet.nsc.ru
• 关键词：gene network – ; nonlinear dynamical system – ; stationary point – ; drosophila – ; neurogenesis – ; achaete ; scute complex
• 刊名：Journal of Applied and Industrial Mathematics
• 出版年：2012
• 出版时间：April 2012
• 年：2012
• 卷：6
• 期：2
• 页码：145-149
• 全文大小：404.1 KB
• 参考文献：1. D. P. Furman and T. A. Bukharina, “How Drosophila Melanogaster Forms Its Mechanoreceptors,” Current Genomics 8, 312–323 (2008).
  2. D. P. Furman and T. A. Bukharina, “The Gene Network Determining Development of Drosophila Melanogaster Mechanoreceptors,” Comp. Biol. Chem. 33, 231–234 (2009).
  3. D. P. Furman and T. A. Bukharina, “Genetic Regulation of Morphogenesis of Drosophila Melanogaster Macrochaetes,” Ontogenez 39(4), 245–258 (2008).
  4. D. P. Furman and T. A. Bukharina, “Morphogenesis of Drosophila Melanogaster Macrochaetes: Cell Fate Determination for Bristle Organ,” in Daughter Cells: Properties, Characteristics, and Stem Cells Ed. by A. Hitomi and M. Katoaka (Nova Sci, New York, 2010), pp. 129–162.
  5. C. V. Cabrera and M. C. Alonso, “Transcriptional Activation by Heterodimers of the Achaete-Scute and Daughterless Gene Products of Drosophila,” EMBO J. 10, 2965–2973 (1991).
  6. C. V. Cabrera, M. C. Alonso, and H. Huikeshoven, “Regulation of Scute Function by Extramacrochaete in vitro and in vivo,” Development 120, 3595–3603 (1994).
  7. L. M. Escudero, E. Caminero, K. L. Schulze, H. J. Bellen, and J. Modolell, “Charlatan, a Zn Finger Transcription Factor, Establishes a Novel Level of Regulation of the Proneural Achaete/Scute Genes of Drosophila,” Development 132, 1211–1222 (2005).
  8. R. Nolo, L. A. Abbott, and H. J. Bellen, “Senseless, a Zn Finger Transcription Factor, is Necessary and Sufficient for Sensory Organ Development in Drosophila,” Cell. 102, 349–362 (2000).
  9. J. E. Smith, 3rd, and C. Cronmiller, “The Drosophila Daughterless Gene Autoregulates and Is Controlled by Both Positive and Negative Cis Regulation,” Development 128, 4705–4714 (2001).
  10. H. Vaessin, M. Brand, L. Y. Jan, and Y. N. Jan, “Daughterless is Essential for Neuronal Precursor Differentiation but not for Initiation of Neuronal Precursor Formation in Drosophila Embryo,” Development 120, 935–945 (1994).
  11. M. Van Doren, A. M. Bailey, J. Esnayra, K. Ede, and J. W. Posakony, “Negative Regulation of Proneural Gene Activity: Hairy is a Direct Transcriptional Repressor of Achaete,” Genes Dev. 8, 2729–2749 (1994).
  12. M. Van Doren, P. A. Powell, D. Pasternak, A. Singson, and J.W. Posakony, “Spatial Regulation of Proneural Gene Activity: Auto- and Cross-Activation of Achaete is Antagonized by Extramacrochaetae,” GenesDev. 6, 2592–2605 (1992).
  13. M. Roark, M. A. Sturtevant, J. Emery, H. Vaessin, E. Grell, and E. Bier, “Scratch, a Pan-Neural Gene Encoding a Zinc Finger Protein Related to Snail, Promotes Neuronal Development,” Genes Dev. 9, 2384–2398 (1995).
  14. V. A. Likhoshvai, V. P. Golubyatnikov, G. V. Demidenko, A. A. Evdokimov, and S. I. Fadeeev, “Gene Network Theory,” in Systematic Gene Biology, Ed. by N. A. Kolchanov and S. S. Goncharov (Siberian Division of the Russian Academy of Sciences, Novosibirsk, 2008), pp. 395–480.
  15. Yu. A. Gaidov and V. P. Golubyatnikov, “Some Nonlinear Dynamical Systems Modeling the Asymmetrical Gene Networks,” Vestnik Novosib. Gos. Univ. 7(2), 23–32 (2007).
  16. V. P. Golubyatnikov, I. V. Golubyatnikov, and V. A. Likhoshvai, “On Existence and Stability of Cycles in Five-Dimensional Models of Gene Networks,” Sibirsk. Zh. Vychisl. Mat. 13(4), 403–411 (2010) [Numer. Anal. Appl. 3 (4), 329–335 (2010)].
• 作者单位：1. Institute of Cytology and Genetics, pr. Akad. Lavrent鈥檈va 10, Novosibirsk, 630090 Russia2. Sobolev Institute of Mathematics, pr. Akad. Koptyuga 4, Novosibirsk, 630090 Russia3. Novosibirsk State University, ul. Pirogova 2, Novosibirsk, 630090 Russia
• 刊物类别：Mathematics and Statistics
• 刊物主题：Mathematics
  Mathematics
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1990-4797

文摘

The mechanoreceptors (in particular, macrochaetes) of drosophila pass three stages in its development (morphogenesis) whose genetic support is described in terms of gene networks. The key object of the gene networks of macrochaete morphogenesis is the achaete-scute (AS-C) complex of genes. Each mechanoreceptor develops from one parent cell distinguished by high concentration of the AS-C protein. The activity of this complex, which ensures the protein concentration critical for initiating morphogenesis, is determined by the central regulatory contour which includes a system of interactions among certain objects of the networks (genes and their products).