Blood-based signatures in type 1 diabetes
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- 作者：Susanne M. Cabrera ; Yi-Guang Chen ; William A. Hagopian ; Martin J. Hessner
- 关键词：Biomarker ; Gene expression profiling ; Innate immunity ; Microarray ; Review ; Type 1 diabetes
- 刊名：Diabetologia
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：59
- 期：3
- 页码：414-425
- 全文大小：885 KB
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Yi-Guang Chen (1) (2)
William A. Hagopian (3)
Martin J. Hessner (1) (2)
1. The Max McGee National Research Center for Juvenile Diabetes, Children’s Research Institute of Children’s Hospital of Wisconsin, Milwaukee, WI, USA
2. Section of Endocrinology, Department of Pediatrics, The Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA
3. Pacific Northwest Diabetes Research Institute, Seattle, WA, USA - 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Internal Medicine
Metabolic Diseases
Human Physiology - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-0428
文摘
Type 1 diabetes mellitus is one of the most common chronic diseases in childhood. It develops through autoimmune destruction of the pancreatic beta cells and results in lifelong dependence on exogenous insulin. The pathogenesis of type 1 diabetes involves a complex interplay of genetic and environmental factors and has historically been attributed to aberrant adaptive immunity; however, there is increasing evidence for a role of innate inflammation. Over the past decade new methodologies for the analysis of nucleic acid and protein signals have been applied to type 1 diabetes. These studies are providing a new understanding of type 1 diabetes pathogenesis and have the potential to inform the development of new biomarkers for predicting diabetes onset and monitoring therapeutic interventions. In this review we will focus on blood-based signatures in type 1 diabetes, with special attention to both direct transcriptomic analyses of whole blood and immunocyte subsets, as well as plasma/serum-induced transcriptional signatures. Attention will also be given to proteomics, microRNA assays and markers of beta cell death. We will also discuss the results of blood-based profiling in type 1 diabetes within the context of the genetic and environmental factors implicated in the natural history of autoimmune diabetes. Keywords Biomarker Gene expression profiling Innate immunity Microarray Review Type 1 diabetes